A simplified approach to critically appraising research evidence
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Updated: Nov 15, 2025

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
Peter Raby1, Rebekah Jayne McNaughton1
1School of Health and Life Sciences, Teesside University, Middlesbrough, England.
Abstract:
Background Evidence-based practice is embedded in all aspects of nursing and care. Understanding research evidence and being able to identify the strengths, weaknesses and limitations of published primary research is an essential skill of the evidence-based practitioner. However, it can be daunting and seem overly complex.
Aim:
To provide a single framework that researchers can use when reading, understanding and critically assessing published research.
Discussion:
To make sense of published research papers, it is helpful to understand some key concepts and how they relate to either quantitative or qualitative designs. Internal and external validity, reliability and trustworthiness are discussed. An illustration of how to apply these concepts in a practical way using a standardised framework to systematically assess a paper is provided.
Conclusion:
The ability to understand and evaluate research builds strong evidence-based practitioners, who are essential to nursing practice.
Implications For Practice:
This framework should help readers to identify the strengths, potential weaknesses and limitations of a paper to judge its quality and potential usefulness.
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