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Updated: Nov 15, 2025

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RNAscope for In situ Detection of Transcriptionally Active Human Papillomavirus in Head and Neck Squamous Cell Carcinoma
Published on: March 11, 2014
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What every dentist needs to know about human papillomavirus
General Dentistry
|March 4, 2021
Summary
Human papillomavirus (HPV) is common globally and linked to oropharyngeal cancers. Oral health professionals must screen for HPV manifestations and advocate for vaccination to improve patient outcomes.
Area of Science:
- Oral Health
- Oncology
- Infectious Diseases
Background:
- Human papillomavirus (HPV) infection is nearly ubiquitous worldwide in adolescents and adults.
- While historically linked to cervical and uterine cancers, HPV is increasingly associated with oropharyngeal squamous cell carcinoma in both sexes.
Purpose of the Study:
- To review the oral health implications of HPV infection.
- To discuss prevalence, manifestations, neoplastic potential, and treatment of HPV-associated head and neck lesions.
- To highlight the role of oral healthcare providers in patient screening, referral, and HPV vaccination advocacy.
Main Methods:
- Literature review of HPV infection in oral and oropharyngeal contexts.
- Analysis of neoplastic potential and treatment modalities for HPV-associated lesions.
- Discussion of vaccine use and continuing education needs for dental professionals.
Main Results:
- HPV infection presents various oral and oropharyngeal manifestations.
- HPV-associated head and neck lesions carry neoplastic potential.
- Effective screening, timely referral, and vaccination are crucial for managing HPV's oral health impact.
Conclusions:
- Oral healthcare providers play a vital role in identifying and managing HPV-related oral conditions.
- Routine screening for oral HPV manifestations is recommended for all patients.
- Promoting HPV vaccination is essential for preventing HPV-associated cancers.
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