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[Cancer-associated genodermatoses].

L H Frommherz1, O K Steinlein2, L E French1

  • 1Klinik für Dermatologie und Allergologie, LMU Klinikum, Frauenlobstr. 9-11, 80337, München, Deutschland.

Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete
|March 4, 2021
PubMed
Summary
This summary is machine-generated.

Hereditary tumor syndromes involve familial cancer occurrences, often in younger individuals. Early diagnosis through skin symptoms, genetic testing, and regular surveillance is crucial due to the lack of curative therapies.

Keywords:
Birt-Hogg-Dubé syndromeCarney complexCowden syndromeHereditary tumor syndromeMuir-Torre syndrome

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Area of Science:

  • Oncology
  • Genetics
  • Dermatology

Background:

  • Hereditary tumor syndromes present as familial cancer occurrences.
  • Suspicion arises with family cancer history or early-onset cancers.
  • Specific skin manifestations can aid in diagnosing these syndromes.

Purpose of the Study:

  • To highlight the importance of recognizing hereditary tumor syndromes.
  • To emphasize the role of cutaneous signs in diagnosis.
  • To outline recommended diagnostic and management strategies.

Main Methods:

  • Review of clinical characteristics of known hereditary tumor syndromes.
  • Identification of associated dermatological findings.
  • Discussion of genetic testing, counseling, and surveillance protocols.

Main Results:

  • Specific skin symptoms like fibrofolliculoma, epidermal/sebaceous cysts, neurofibroma, sebaceous neoplasms, and keratoacanthoma are linked to distinct syndromes (Birt-Hogg-Dubé, Gardner, Muir-Torre).
  • Genetic testing and counseling are recommended for affected individuals and families.
  • Regular clinical surveillance is advised for management.

Conclusions:

  • Early identification of hereditary tumor syndromes is critical.
  • Cutaneous signs serve as valuable diagnostic clues.
  • Preventive screening and surveillance are paramount in the absence of curative treatments.