Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Esophageal Strictures-I: Introduction01:30

Esophageal Strictures-I: Introduction

378
Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
378
Esophagus01:24

Esophagus

2.7K
The esophagus, a muscular conduit linking the pharynx and stomach, measures roughly 10 inches (25.4 cm) and sits behind the trachea. It remains collapsed when not swallowing. The esophagus follows a predominantly straight path through the thoracic mediastinum and enters the abdominal cavity through a diaphragmatic opening known as the esophageal hiatus.
The movement of edibles from the pharynx into the esophagus is facilitated by the upper esophageal sphincter, which is formed primarily by the...
2.7K
Barrett Esophagus-II: Clinical Manifestations and Management01:21

Barrett Esophagus-II: Clinical Manifestations and Management

450
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
450
Barrett Esophagus-I: Introduction01:21

Barrett Esophagus-I: Introduction

353
Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
353
Stimulants01:29

Stimulants

618
Stimulants are substances that enhance neural activity and elevate dopamine levels in the brain, leading to their highly addictive nature. These drugs include cocaine, amphetamines, MDMA, caffeine, and nicotine, each with distinct mechanisms of action and varied health implications.
Cocaine can be administered via snorting, injection, or smoking. It primarily functions by blocking the reuptake of dopamine, resulting in a euphoric high characterized by an intense sensation of happiness and...
618
Gastroesophageal Reflux Disease I: Meaning and Pathophysiology01:29

Gastroesophageal Reflux Disease I: Meaning and Pathophysiology

767
Gastroesophageal Reflux Disease (GERD) involves the recurrent backflow of the stomach or duodenal contents into the esophagus, leading to troublesome symptoms and potential esophageal mucosal damage. Although GERD is often referred to as a disease, it is more accurately described as a syndrome, as it encompasses a range of symptoms and complications rather than a singular pathological entity, impacting a large number of individuals as the most prevalent upper gastrointestinal problem. Roughly...
767

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Association of Frailty and Delirium with Hospitalization Outcomes Among Older Adults With Rheumatic Diseases.

ACR open rheumatology·2026
Same author

Associations Between Physical Activity and Irritable Bowel Syndrome in the All of Us Research Program.

The American journal of gastroenterology·2026
Same author

A Prospective Study Characterizing Cognitive Function in Patients With Inflammatory Bowel Disease.

Clinical and translational gastroenterology·2026
Same author

Frailty in inflammatory bowel disease: a missing link in personalized care for the aging IBD population.

Inflammatory bowel diseases·2026
Same author

Ulcerative colitis, frailty, and beyond.

Expert review of gastroenterology & hepatology·2026
Same author

Differences in Outcomes After Ileocecal Resection in Older Adults With Crohn's Disease in the Biologic Era.

The American journal of gastroenterology·2026
Same journal

Uncommon initial presentation of a gastric mass in a patient with primary plasma cell leukemia: a case report.

BMC gastroenterology·2026
Same journal

Examining the effect of nurse navigation programme on stoma adjustment, quality of life, and prevention of complications in patients with stoma: a randomized controlled trial.

BMC gastroenterology·2026
Same journal

Determinants of eligibility for second-line chemotherapy following gemcitabine plus nab-paclitaxel therapy in patients with unresectable pancreatic cancer: a retrospective study.

BMC gastroenterology·2026
Same journal

Integrating WGCNA and machine learning to identify and validate key biomarkers in MASLD.

BMC gastroenterology·2026
Same journal

Predictive factors and nomogram for post-endoscopic retrograde cholangiopancreatography pancreatitis.

BMC gastroenterology·2026
Same journal

Associations between childhood behavior and current cognitive and emotional function in adults with irritable bowel syndrome-a cross sectional retrospective study.

BMC gastroenterology·2026
See all related articles

Related Experiment Video

Updated: Nov 15, 2025

Generation of Electronic Cigarette Aerosol by a Third-Generation Machine-Vaping Device: Application to Toxicological Studies
08:39

Generation of Electronic Cigarette Aerosol by a Third-Generation Machine-Vaping Device: Application to Toxicological Studies

Published on: August 25, 2018

26.1K

Vaping-associated esophagitis.

Trisha Satya Pasricha1, Bharati Kochar2,3

  • 1Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School Boston, 55 Fruit Street, Boston, MA, 02114, USA. tpasricha@mgh.harvard.edu.

BMC Gastroenterology
|March 5, 2021
PubMed
Summary
This summary is machine-generated.

Vaping may cause severe esophagitis, a serious gastrointestinal complication. Clinicians should inquire about vaping history, as nicotine may be the cause, similar to smoking.

Keywords:
Case reportE-cigarettesEsophagitisOdynophagiaVaping

More Related Videos

Comparing the Effects of Electronic Cigarette Vapor and Cigarette Smoke in a Novel In Vivo Exposure System
10:44

Comparing the Effects of Electronic Cigarette Vapor and Cigarette Smoke in a Novel In Vivo Exposure System

Published on: May 24, 2017

11.8K
Development of Compendium for Esophageal Squamous Cell Carcinoma
03:36

Development of Compendium for Esophageal Squamous Cell Carcinoma

Published on: April 12, 2024

652

Related Experiment Videos

Last Updated: Nov 15, 2025

Generation of Electronic Cigarette Aerosol by a Third-Generation Machine-Vaping Device: Application to Toxicological Studies
08:39

Generation of Electronic Cigarette Aerosol by a Third-Generation Machine-Vaping Device: Application to Toxicological Studies

Published on: August 25, 2018

26.1K
Comparing the Effects of Electronic Cigarette Vapor and Cigarette Smoke in a Novel In Vivo Exposure System
10:44

Comparing the Effects of Electronic Cigarette Vapor and Cigarette Smoke in a Novel In Vivo Exposure System

Published on: May 24, 2017

11.8K
Development of Compendium for Esophageal Squamous Cell Carcinoma
03:36

Development of Compendium for Esophageal Squamous Cell Carcinoma

Published on: April 12, 2024

652

Area of Science:

  • Gastroenterology
  • Toxicology
  • Public Health

Background:

  • Vaping (e-cigarettes) is increasingly popular globally, with 41 million users.
  • Unlike tobacco smoking, the gastrointestinal effects of vaping remain largely unknown.
  • This study details a novel case of severe esophagitis linked to vaping.

Observation:

  • A 25-year-old male with GERD developed severe odynophagia after two months of heavy vaping (nicotine and THC).
  • Endoscopy revealed Los Angeles Grade C esophagitis; biopsies showed inflammation and granulation tissue.
  • Other causes like infections and eosinophilic esophagitis were ruled out.

Findings:

  • Vaping, particularly with nicotine, can lead to severe esophageal inflammation (esophagitis).
  • The patient's symptoms resolved completely after vaping cessation and PPI treatment.
  • Histopathology confirmed severe esophageal injury without infectious or allergic etiology.

Implications:

  • Vaping poses significant gastrointestinal risks, potentially similar to smoking due to nicotine.
  • Clinicians must actively ask about vaping history, as patients may not identify it as "smoking."
  • Further research is crucial to understand the long-term gastrointestinal consequences of vaping.