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Related Concept Videos

Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...

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Investigating Intestinal Inflammation in DSS-induced Model of IBD
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A Prospective Study Characterizing Cognitive Function in Patients With Inflammatory Bowel Disease.

Praachi Raje1,2, Tom A D Stone1,3,4, Joudi Alkourabi1

  • 1Department of General and Gastrointestinal Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA.

Clinical and Translational Gastroenterology
|April 17, 2026
PubMed
Summary
This summary is machine-generated.

Cognitive impairment is common in Inflammatory Bowel Disease (IBD) patients, who show no difference in EEG alpha power but lack cognitive improvement over time compared to controls.

Keywords:
cognitive functioncolonoscopyelectroencephalographyinflammatory bowel disease

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Area of Science:

  • Neuroscience
  • Gastroenterology
  • Cognitive Science

Background:

  • Inflammatory Bowel Disease (IBD) is potentially linked to cognitive impairment.
  • Cognitive decline correlates with reduced alpha wave activity on electroencephalography (EEG).

Purpose of the Study:

  • To investigate the relationship between cognitive function and EEG alpha power in patients with IBD.
  • To compare cognitive performance and EEG metrics between IBD patients and healthy controls.

Main Methods:

  • A prospective cohort study involving IBD patients and controls undergoing colonoscopy.
  • Preprocedural cognitive testing using the Brain Health Assessment (BHA) and intraprocedural EEG monitoring.
  • Follow-up cognitive assessments 6-18 months post-procedure.

Main Results:

  • Both IBD patients and controls showed moderate cognitive impairment likelihood on BHA.
  • No significant differences in EEG alpha power were observed between the groups after adjusting for covariates.
  • Controls exhibited improved cognitive performance at follow-up, whereas IBD patients did not.

Conclusions:

  • Preprocedural cognitive impairment is present in both IBD patients and controls, without differences in EEG alpha power.
  • The absence of cognitive improvement in IBD patients suggests potentially lower baseline function and warrants further research.