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Transauricular Vagus Nerve Stimulation and Electroencephalographic Assessment in Disorders of Consciousness

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Auditory Stimulation Modulates Resting-State Functional Connectivity in Unresponsive Wakefulness Syndrome Patients.

Melanie Boltzmann¹, Simone B Schmidt¹, Christoph Gutenbrunner²

¹BDH-Klinik Hessisch Oldendorf, Hessisch Oldendorf, Germany.

Frontiers in Neuroscience

|March 5, 2021

Summary

Preferred music can modulate brain activity in patients with unresponsive wakefulness syndrome (UWS). This study found that music listening impacts functional connectivity in UWS patients, unlike in healthy controls.

Keywords:

auditory stimulation disorders of consciousness neurological early rehabilitation resting-state fMRI unresponsive wakefulness syndrome

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Published on: November 13, 2016

Area of Science:

Neuroscience
Cognitive Science
Neurology

Background:

Passive music listening offers psychological and physical benefits across populations.
Altered brain activity and functional connectivity characterize unresponsive wakefulness syndrome (UWS).

Purpose of the Study:

To investigate the effects of preferred music on resting-state functional connectivity in patients with UWS.
To compare brain responses to auditory stimuli between UWS patients and healthy controls (HC).

Main Methods:

Functional magnetic resonance imaging (fMRI) was used to analyze resting-state functional connectivity.
Participants (13 UWS patients, 18 HC) were exposed to scanner noise, preferred music, and aversive auditory stimulation.
A seed-based approach was employed for functional connectivity analysis.

Main Results:

Healthy controls showed no significant differences in network connectivity across auditory conditions.
UWS patients exhibited impaired functional connectivity across all resting-state networks.
Preferred and aversive auditory stimulation modulated the functional connectivity of the auditory network in UWS patients.

Conclusions:

Auditory stimulation, particularly preferred music, has the potential to modulate brain activity in UWS patients.
Findings suggest music's therapeutic potential for modulating consciousness and brain function in UWS.