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Updated: Nov 15, 2025

Activation and Measurement of NLRP3 Inflammasome Activity Using IL-1β in Human Monocyte-derived Dendritic Cells
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The Role of NLRP3 Inflammasome in Pericarditis: Potential for Therapeutic Approaches

Adolfo G Mauro1,2, Aldo Bonaventura1,2,3, Alessandra Vecchié1,2

  • 1Pauley Heart Center, Division of Cardiology, Department of Internal Medicine, Virginia Commonwealth University, Richmond, Virginia, USA.

JACC. Basic to Translational Science
|March 5, 2021
PubMed

Human samples of patients with chronic pericarditis and appropriate control subjects were stained for the inflammasome components. A mouse model of pericarditis was developed through the intrapericardial injection of zymosan A. Different inflammasome blockers were tested in the mouse model. Patients with pericarditis presented an intensification of the inflammasome activation compared with control subjects. The experimental model showed the pathological features of pericarditis. Among inflammasome blockers, NLRP3 inflammasome inhibitor, anakinra, and interleukin-1 trap were found to significantly improve pericardial alterations. Colchicine partially improved the pericardial inflammation. An intense activation of the inflammasome in pericarditis was demonstrated both in humans and in mice.

Keywords:
IL, interleukinIL-1 trapIL-1αIL-1βNLRP3 inflammasomeNLRP3inh, NLRP3 inflammasome inhibitoranakinracolchicinepericarditis

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