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Updated: Nov 15, 2025
06:51
Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291
Published on: December 10, 2016
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Risk factors for development of initial Clostridioides difficile infection
Jamie L Wagner1, Kayla R Stover2, Allison M Bell3
1University of Mississippi School of Pharmacy, Department of Pharmacy Practice, 2500 N. State Street, Jackson, MS 39216, USA.
Journal of Global Antimicrobial Resistance
|March 5, 2021
Summary
Identifying risk factors for complicated Clostridioides difficile infection (CDI) is crucial. Fluoroquinolone exposure and longer carbapenem use increased complicated CDI risk, while abdominal surgery decreased it.
Area of Science:
- Infectious Diseases
- Microbiology
- Clinical Medicine
Background:
- Clostridioides difficile infection (CDI) poses a significant healthcare challenge.
- Understanding risk factors for complicated CDI is essential for improving patient outcomes.
- Initial episodes of CDI can range from uncomplicated to severe, complicated forms.
Purpose of the Study:
- To identify key risk factors associated with initial complicated Clostridioides difficile infection (CDI).
- To differentiate between factors contributing to complicated versus uncomplicated initial CDI episodes.
Main Methods:
- Retrospective cross-sectional study design.
- Inclusion of adult patients with initial CDI episodes receiving ≥72 hours of CDI-active antimicrobials.
- Categorization into complicated CDI (abnormal CT or 30-day mortality) or uncomplicated CDI groups.
Main Results:
- Nearly one-third of patients (29.6%) experienced complicated initial CDI.
- Complicated CDI patients showed higher rates of prior fluoroquinolone exposure (48.3% vs. 30.8%) and longer carbapenem exposure (7 vs. 3 days).
- Logistic regression indicated fluoroquinolone exposure as a risk factor and prior abdominal surgery as a protective factor for complicated CDI.
Conclusions:
- A substantial proportion of initial CDI episodes manifest as complicated infections.
- Prior fluoroquinolone exposure is a significant risk factor for complicated CDI.
- Further research is needed to fully understand the impact of antibiotic history on complicated CDI development.
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