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Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
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SIRT1 and SIRT2 Modulators: Potential Anti-Inflammatory Treatment for Depression?

Yuqing Zhang1,2,3, Shailendra Anoopkumar-Dukie1,2,3, Andrew Keith Davey1,2,3

  • 1Menzies Health Institute Queensland, Griffith University, Gold Coast, QLD 4222, Australia.

Biomolecules
|March 6, 2021
PubMed
Summary
This summary is machine-generated.

Neuroinflammation is linked to depression. This review explores how SIRT1 and SIRT2 proteins influence inflammation and depressive behaviors, suggesting potential new anti-inflammatory treatments for depression.

Keywords:
SIRT1SIRT2clinical studydepressioninflammationpolymorphism

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Deacetylation Assays to Unravel the Interplay between Sirtuins SIRT2 and Specific Protein-substrates
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Area of Science:

  • Neuroscience
  • Psychiatry
  • Molecular Biology

Background:

  • Depression presents a significant global health challenge with limited efficacy of current monoamine-targeting antidepressants.
  • Emerging research highlights the role of neuroinflammation in depression's development and progression.
  • Sirtuins, NAD+-dependent deacetylases, are implicated in inflammatory processes.

Purpose of the Study:

  • To review the association between Sirtuin 1 (SIRT1) and Sirtuin 2 (SIRT2) activity and depression.
  • To examine the impact of SIRT1 and SIRT2 modulators on inflammation and depressive behaviors.

Main Methods:

  • Literature review focusing on studies investigating SIRT1 and SIRT2 in the context of inflammation and depression.
  • Analysis of in vitro data on SIRT1/SIRT2 modulators' effects on inflammatory pathways.
  • Evaluation of in vivo studies examining SIRT1/SIRT2 modulators' impact on depressive-like behaviors.

Main Results:

  • SIRT1 and SIRT2 are involved in the pathophysiology of inflammation.
  • Modulators of SIRT1 and SIRT2 show potential in affecting inflammatory markers.
  • Evidence suggests SIRT1 and SIRT2 modulation may influence depressive-like behaviors in preclinical models.

Conclusions:

  • SIRT1 and SIRT2 represent promising therapeutic targets for depression.
  • Targeting neuroinflammation via SIRT1 and SIRT2 modulation could offer novel treatment strategies for depression.
  • Further research into SIRT1 and SIRT2 pathways is warranted for developing effective anti-inflammatory antidepressants.