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Updated: Nov 15, 2025

Isolation of Primary Mouse Hepatocytes for Nascent Protein Synthesis Analysis by Non-radioactive L-azidohomoalanine Labeling Method
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Published on: October 23, 2018

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The Roles of Post-Translational Modifications on mTOR Signaling

Shasha Yin1, Liu Liu1, Wenjian Gan1

  • 1Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, USA.

International Journal of Molecular Sciences
|March 6, 2021
PubMed

Insights

The mechanistic target of rapamycin (mTOR) pathway regulates cell growth and metabolism. This review details how post-translational modifications (PTMs) affect mTOR signaling and disease, and discusses therapeutic strategies targeting mTOR.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • The mechanistic target of rapamycin (mTOR) pathway is a central regulator of cell growth, proliferation, metabolism, and synthesis of macromolecules.
  • mTOR signaling integrates environmental cues like growth factors, nutrients, and energy status to control fundamental cellular processes.
  • Dysregulation of mTOR signaling is implicated in numerous human diseases, including cancers and metabolic disorders.

Purpose of the Study:

  • To review the current understanding of post-translational modifications (PTMs) in regulating mTOR signaling.
  • To update on therapeutic strategies targeting the mTOR pathway and associated PTMs for disease treatment.

Main Methods:

  • Literature review of PTMs' role in mTOR signaling.
  • Analysis of PTM-mediated regulation in various pathologies.
  • Summary of current therapeutic approaches targeting mTOR and PTMs.

Main Results:

  • PTMs are critical regulators of mTOR pathway activity, often contributing to disease pathogenesis.
  • Aberrant PTMs on mTOR components are significant drivers of pathologies.
  • Targeting mTOR and PTM-related enzymes shows promise for treating human diseases.

Conclusions:

  • Understanding PTMs' role in mTOR signaling is crucial for deciphering disease mechanisms.
  • Therapeutic interventions targeting the mTOR pathway and PTMs offer potential treatment avenues for various diseases.
Keywords:
human diseasesinhibitorsmTORpost-translational modifications

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