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Review on Inflammation Markers in Chronic Kidney Disease

Tadej Petreski1,2, Nejc Piko1,3, Robert Ekart2,3

  • 1Department of Nephrology, Clinic for Internal Medicine, University Medical Centre Maribor, Ljubljanska Ulica 5, 2000 Maribor, Slovenia.

Biomedicines
|March 6, 2021
PubMed

Insights

Chronic kidney disease (CKD) affects millions globally. This review examines inflammation markers, including cytokines and chemokines, as key factors in CKD development and progression, highlighting the need for further research.

Area of Science:

  • Nephrology
  • Immunology
  • Public Health

Background:

  • Chronic kidney disease (CKD) is a significant global health issue with increasing prevalence.
  • Identifying CKD risk factors and progression drivers is crucial for public health.
  • Recent research has uncovered novel markers and insights into CKD pathogenesis.

Purpose of the Study:

  • To review the role of inflammation markers in the development and progression of CKD.
  • To focus on specific inflammatory markers: cytokines, chemokines, and cell adhesion molecules.
  • To summarize current evidence and identify gaps in understanding.

Main Methods:

  • Literature review of studies on inflammation markers and CKD.
  • Focus on cytokines, chemokines, and cell adhesion molecules.
  • Synthesis of evidence regarding their role in CKD pathogenesis.

Main Results:

  • Inflammation markers, including cytokines and chemokines, are implicated in CKD development.
  • These markers play a role in the progression of chronic kidney disease.
  • Evidence suggests a link between cell adhesion molecules and CKD.

Conclusions:

  • Inflammation markers are important in understanding CKD.
  • Further large-scale, multicenter studies are required.
  • Clinical validation of these markers and potential treatments is needed.

Keywords:
cell adhesion moleculeschemokineschronic kidney diseasecytokinesinflammation markers

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