Targeted Hybrid Nanocarriers as a System Enhancing the Skin Structure

Area of Science:

• Cosmetic Science
• Materials Science
• Dermatology

Background:

• Skin health is compromised by various internal and external factors.
• Nanosystems offer advanced delivery for cosmetic and therapeutic agents.
• Levan nanoparticles and nanoemulsions are explored for their potential in skin care.

Purpose of the Study:

• To characterize levan nanoparticles and surfactin-stabilized nanoemulsions.
• To incorporate these nanosystems into prototype skincare formulations (cream, tonic, gel).
• To evaluate the efficacy of these formulations in improving skin condition.

Main Methods:

• Characterization of nanosystems (size, polydispersity, Zeta potential, stability) and morphology (TEM).
• Assessment of antiradical activity using DPPH scavenging and EPR spectroscopy.
• In vivo evaluation of prototype formulations for skin hydration, elasticity, smoothness, wrinkles, and discoloration.

Main Results:

• Nanoemulsions exhibited spherical morphology (220-300 nm); levan nanoparticles had irregular shapes (130-260 nm).
• Both nanosystems demonstrated antiradical effects.
• The cream formulation improved skin hydration, elasticity, and smoothness in over 50% of volunteers.
• Comprehensive care (cream, tonic, gel) reduced skin discoloration by 10.42%.

Conclusions:

• Levan nanoparticles and nanoemulsions are stable and suitable for skincare formulations.
• The developed prototype formulations show significant potential for enhancing skin condition.
• These nanosystems represent a promising approach for advanced dermatological and cosmetic applications.