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Regulation of ZMYND8 to Treat Cancer

Yun Chen1,2, Ya-Hui Tsai1,2, Sheng-Hong Tseng1,3

  • 1Department of Surgery, Far Eastern Memorial Hospital, Pan-Chiao, New Taipei 220, Taiwan.

Molecules (Basel, Switzerland)
|March 6, 2021
PubMed

Insights

Zinc finger MYND-type containing 8 (ZMYND8) has a dual role in cancer, acting as both an oncogene and tumor suppressor. Further research is needed to clarify its complex role in tumorigenesis and potential therapeutic applications.

Area of Science:

  • Molecular Biology
  • Cancer Research
  • Epigenetics

Background:

  • ZMYND8 is a transcription factor and chromatin regulator crucial for normal cellular processes.
  • Altered ZMYND8 expression is implicated in various cancers, including breast, prostate, and colorectal.
  • Its precise role in tumorigenesis remains unclear due to contradictory findings.

Purpose of the Study:

  • To review the current understanding of ZMYND8's function in cancer.
  • To highlight the contradictory roles of ZMYND8 as both an oncogene and tumor suppressor.
  • To emphasize the need for further research into ZMYND8's mechanisms in tumorigenesis.

Main Methods:

  • Literature review of studies investigating ZMYND8 in cancer.
  • Analysis of ZMYND8's known functions as a transcription factor and chromatin regulator.
  • Comparison of studies reporting increased versus decreased ZMYND8 expression in different cancer types.

Main Results:

  • Increased ZMYND8 expression is linked to pro-oncogenic effects and angiogenesis in breast and prostate cancers.
  • Downregulation of ZMYND8 is observed in breast, prostate, and nasopharyngeal cancers, where it acts as a tumor suppressor.
  • ZMYND8's tumor-suppressive functions include promoting differentiation and inhibiting proliferation and metastasis.

Conclusions:

  • ZMYND8 plays a significant, albeit complex and contradictory, role in tumorigenesis.
  • Its dual function as an oncogene and tumor suppressor necessitates further investigation.
  • Targeting ZMYND8 or its binding partners may offer future therapeutic strategies for cancer treatment.
Keywords:
ZMYND8epigenetic regulationpro-oncogenic effectstumor suppressiontumorigenesis

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