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Nano-Interstice Driven Powerless Blood Plasma Extraction in a Membrane Filter Integrated Microfluidic Device.
Jaehoon Kim1, Junghyo Yoon2, Jae-Yeong Byun1
1School of Mechanical Engineering, Korea University, Seoul 02841, Korea.
Sensors (Basel, Switzerland)
|March 6, 2021
Summary
This study presents a novel microfluidic device for rapid blood plasma extraction without external equipment. The device achieves high plasma yield, enabling efficient point-of-care testing applications.
Area of Science:
- Biomedical Engineering
- Microfluidics
- Biomarker Discovery
Background:
- Blood plasma is crucial for biomarker analysis.
- Current extraction methods are often complex and time-consuming for point-of-care testing (POCT).
- A need exists for simple, rapid plasma separation techniques.
Purpose of the Study:
- To develop a novel microfluidic device for efficient blood plasma extraction.
- To enable plasma separation without external instrumentation for POCT.
- To achieve high plasma yield and purity.
Main Methods:
- Integration of a commercial membrane filter with a custom-designed dual-cover microfluidic device.
- Utilized nano-interstices within microfluidic channels to actively draw plasma.
- Evaluated device performance for plasma extraction from whole blood.
Main Results:
- Successfully extracted 20 μL of blood plasma.
- Achieved a high extraction yield of approximately 45%.
- Completed plasma extraction within 16 minutes.
Conclusions:
- The developed membrane filter-integrated microfluidic device offers a simple and efficient solution for blood plasma extraction.
- The device's design prevents leakage and maintains plasma integrity.
- This technology holds promise for advancing point-of-care diagnostic applications.
