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Color Spot Test As a Presumptive Tool for the Rapid Detection of Synthetic Cathinones
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Structure Assignment of Seized Products Containing Cathinone Derivatives Using High Resolution Analytical Techniques.

João L Gonçalves1, Vera L Alves1, Joselin Aguiar1

  • 1CQM-Centro de Química da Madeira, Universidade da Madeira, Campus Universitário da Penteada, 9020-105 Funchal, Portugal.

Metabolites
|March 6, 2021
PubMed
Summary
This summary is machine-generated.

Rapid identification of new psychoactive substances is crucial for public health. This study found synthetic cathinones in all analyzed seized products, highlighting their prevalence in the Portuguese market.

Keywords:
FTIRGC-MSNMRchemical characterizationnew psychoactive substancessynthetic cathinones

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Area of Science:

  • Forensic Chemistry
  • Analytical Chemistry
  • Toxicology

Background:

  • The emergence of new psychoactive substances (NPS) poses significant public health risks.
  • Rapid identification of NPS is essential for harm reduction strategies.
  • Synthetic cathinones (SCat) are a prevalent class of NPS.

Purpose of the Study:

  • To identify illicit substances in seized products from the Portuguese market.
  • To characterize the prevalence and types of synthetic cathinones.
  • To evaluate analytical methods for NPS identification.

Main Methods:

  • Analysis of twelve seized products using attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR).
  • Gas chromatography coupled to mass spectrometry (GC-MS) for substance identification.
  • Nuclear magnetic resonance spectroscopy (NMR) for structural elucidation.

Main Results:

  • Synthetic cathinones (SCat) were detected in all analyzed samples.
  • Eight cathinone derivatives were identified, including MPHP, α-PHP, 3-FMC, methedrone, methylone, buphedrone, N-ethylcathinone, and pentedrone.
  • Caffeine and ethylphenidate were the most common adulterants found.

Conclusions:

  • Synthetic cathinones are prevalent in seized illicit materials in Portugal.
  • A combination of ATR-FTIR, GC-MS, and NMR is effective for rapid and unequivocal NPS identification.
  • Complementary analytical techniques are vital when reference standards are unavailable.