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Fucoxanthin Suppresses Osteoclastogenesis via Modulation of MAP Kinase and Nrf2 Signaling

You-Jung Ha1, Yong Seok Choi2, Ye Rim Oh2

  • 1Division of Rheumatology, Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam 13620, Korea.

Marine Drugs
|March 6, 2021
PubMed

Insights

Fucoxanthin (FX), a seaweed carotenoid, inhibits osteoclast formation and bone resorption. It regulates key signaling pathways, suggesting FX as a potential treatment for bone diseases like osteoporosis.

Area of Science:

  • Biochemistry
  • Cell Biology
  • Pharmacology

Background:

  • Fucoxanthin (FX), a carotenoid from brown seaweed, shows therapeutic promise for bone diseases.
  • The precise mechanisms by which FX influences osteoclastogenesis are not fully understood.

Purpose of the Study:

  • To investigate the effects of FX on osteoclast differentiation and bone resorption.
  • To elucidate the regulatory signaling pathways involved in FX's action on osteoclasts.

Main Methods:

  • In vitro studies using RAW264.7 cells stimulated with RANKL or TNF-α/IL-6.
  • Assessment of osteoclast differentiation, bone resorption, and expression of osteoclast-specific markers.
  • Analysis of intracellular signaling pathways, including mitogen-activated protein kinases (MAPKs) and Nrf2.

Main Results:

  • FX significantly inhibited osteoclast differentiation and bone resorption.
  • FX downregulated osteoclast-specific markers: NFATc1, DCSTAMP, and MMP-9.
  • FX decreased extracellular signal-regulated kinase (ERK) and p38 kinase activation, while increasing Nrf2 nuclear translocation.

Conclusions:

  • Fucoxanthin regulates osteoclastogenesis by modulating MAPK and Nrf2 signaling pathways.
  • FX demonstrates potential as a therapeutic agent for osteoclast-related skeletal disorders, including osteoporosis and rheumatoid arthritis.
Keywords:
MAP kinaseNrf2brown seaweedfucoxanthinosteoclastogenesis

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