Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Radiological Investigation III: Pulmonary Angiogram and PET Scan01:13

Radiological Investigation III: Pulmonary Angiogram and PET Scan

250
Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...
250
Positron Emission Tomography01:29

Positron Emission Tomography

6.5K
Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
6.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Fatty Pancreas and Risk of Type 2 Diabetes, Chronic Kidney Disease and Cardiovascular Events: Evidence From a Population-Based Cohort.

United European gastroenterology journal·2026
Same author

Developing a Core Outcome Measurement Set for Adult ICU Patients, the CoreMS-ICU-A Protocol.

Acta anaesthesiologica Scandinavica·2026
Same author

Venous return versus cardiac function: who drives the circulation?

Intensive care medicine·2026
Same author

[18F]RCCB6 PET/CT in Diagnosing Clear Cell Renal Cell Carcinomas: A Prospective Comparison Study with [18F]FDG PET/CT and Conventional Imaging.

Cancer discovery·2026
Same author

Hybrid [<sup>18</sup>F]FDG PET/MR Imaging Parameters for the Prediction of Tissue Biomarkers in Invasive Ductal Breast Cancer.

Bioengineering (Basel, Switzerland)·2026
Same author

Clinical Criteria for the Definition of Refractory Septic Shock: A Joint Delphi Consensus from the Society of Critical Care Medicine (SCCM) and European Society of Intensive Care Medicine (ESICM).

Critical care medicine·2026

Related Experiment Video

Updated: Nov 15, 2025

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
10:04

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates

Published on: September 5, 2017

19.0K

Long COVID hallmarks on [18F]FDG-PET/CT: a case-control study.

Martina Sollini1,2, Silvia Morbelli3,4, Michele Ciccarelli1

  • 1Humanitas Research Hospital, IRCCS, via Manzoni 56, 20089, Rozzano (Milan), Italy.

European Journal of Nuclear Medicine and Molecular Imaging
|March 7, 2021
PubMed
Summary

Whole-body [18F]FDG-PET/CT imaging revealed multi-organ involvement in long COVID, indicating systemic inflammation. Brain hypometabolism was observed in long COVID patients, correlating with persistent symptoms and highlighting PET/CT

Keywords:
Brain hypometabolismChronic COVID syndromeInfectionInflammationLong COVIDSARS-CoV-2[18F]FDG PET/CT

More Related Videos

Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia
08:05

Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia

Published on: December 19, 2020

14.5K
Quantification of Atherosclerotic Plaque Activity and Vascular Inflammation using [18-F] Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography FDG-PET/CT
10:02

Quantification of Atherosclerotic Plaque Activity and Vascular Inflammation using [18-F] Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography FDG-PET/CT

Published on: May 2, 2012

18.5K

Related Experiment Videos

Last Updated: Nov 15, 2025

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
10:04

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates

Published on: September 5, 2017

19.0K
Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia
08:05

Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia

Published on: December 19, 2020

14.5K
Quantification of Atherosclerotic Plaque Activity and Vascular Inflammation using [18-F] Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography FDG-PET/CT
10:02

Quantification of Atherosclerotic Plaque Activity and Vascular Inflammation using [18-F] Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography FDG-PET/CT

Published on: May 2, 2012

18.5K

Area of Science:

  • Nuclear Medicine
  • Radiology
  • Infectious Diseases
  • Neurology

Background:

  • Long COVID, a condition characterized by persistent symptoms after SARS-CoV-2 infection, presents a complex pathophysiology that remains incompletely understood.
  • Existing diagnostic tools have limitations in fully characterizing the multi-organ systemic effects of long COVID.
  • Positron Emission Tomography/Computed Tomography (PET/CT) with fluorodeoxyglucose (FDG) is a valuable imaging modality for assessing cellular metabolic activity and inflammation.

Purpose of the Study:

  • To investigate the utility of whole-body [18F]FDG-PET/CT in elucidating the pathophysiology of long COVID.
  • To identify potential systemic inflammatory markers and organ-specific metabolic alterations in long COVID patients.
  • To correlate imaging findings with prevalent long COVID symptoms.

Main Methods:

  • Prospective enrollment of 13 adult long COVID patients with persistent symptoms (>30 days post-recovery).
  • Comparison with 26 age- and sex-matched melanoma patients with negative PET/CT scans as controls.
  • Qualitative and semi-quantitative analysis of whole-body [18F]FDG-PET/CT images, including voxel-based analysis for brain metabolism.
  • Statistical comparison using Fisher exact and Mann-Whitney tests.
  • Subgroup analysis based on prevalent symptoms.

Main Results:

  • Mild [18F]FDG uptake in lung abnormalities was noted in 4/13 long COVID patients.
  • Significant differences in Standardized Uptake Values (SUVs) and SUV ratios were observed in multiple organs/parenchyma between long COVID patients and controls (p ≤ 0.05).
  • Long COVID patients demonstrated significant brain hypometabolism in the right parahippocampal gyrus and thalamus (uncorrected p < 0.001).
  • Specific patterns of hypometabolism correlated with persistent anosmia/ageusia, fatigue, and vascular uptake (uncorrected p < 0.005).

Conclusions:

  • Whole-body [18F]FDG-PET/CT imaging supports the multi-organ nature of long COVID and suggests underlying systemic inflammation.
  • The observed brain hypometabolism pattern is associated with persistent long COVID symptoms.
  • Findings suggest a potential differential temporal evolution of brain and systemic inflammatory changes in long COVID, underscoring the value of whole-body [18F]FDG-PET/CT for pathophysiological insights.