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Related Concept Videos

Dosage Regimens: Partial Pharmacokinetic Parameters01:01

Dosage Regimens: Partial Pharmacokinetic Parameters

54
It is not uncommon for complete drug pharmacokinetic profiles to remain elusive in pharmacokinetics. This necessitates certain educated assumptions by pharmacokineticists to determine appropriate dosage regimens without comprehensive pharmacokinetic data from animal or human studies. One prevalent assumption is setting the bioavailability factor, denoted as F, to 1 or 100%. This assumption caters to the scenario where a drug doesn't achieve full systemic absorption, resulting in the patient...
54
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

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Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
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Dosage Regimens: Designs and Approaches01:28

Dosage Regimens: Designs and Approaches

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Designing a dosage regimen, which refers to the manner of drug administration, is a complex process involving the selection of drug dose, route, and frequency. This process is underpinned by pharmacokinetic parameters derived from tests and population averages. These parameters are then tailored to patient-specific variables such as diagnosis, demographics, and allergy status. Once therapy commences, therapeutic response monitoring is critical and achieved through clinical and physical...
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Analysis of Population Pharmacokinetic Data01:12

Analysis of Population Pharmacokinetic Data

536
Analysis of population pharmacokinetic data involves studying the behavior of drugs within diverse populations to understand their pharmacokinetic parameters. Traditional pharmacokinetic methods typically involve collecting samples from a few individuals and estimating these parameters. While these methods are commonly used, they have limitations in capturing the variability in drug response among individuals or heterogeneous populations. Population pharmacokinetics is employed to address these...
536
Dosage Regimen: Individualization01:24

Dosage Regimen: Individualization

68
Individualization in dosing regimens is the customization of medication doses for individual patients. Its necessity arises from the goal of maximizing therapeutic benefits while minimizing risks. This approach is pivotal because human responses to drugs can vary widely; what is effective for one person may be inadequate or excessive for another. Interpatient (intersubject) variability refers to differences in drug responses between individuals, while intrapatient (intrasubject) variability...
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Pharmacovigilance01:19

Pharmacovigilance

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Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
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An Affordable HIV-1 Drug Resistance Monitoring Method for Resource Limited Settings
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Pharmacist eConsult service for primary care medication optimization and safety.

Marie Smith, Erika Vuernick, Daren Anderson

    Journal of the American Pharmacists Association : Japha
    |March 8, 2021
    PubMed
    Summary

    Primary care providers can use clinical pharmacist eConsults to improve medication management. Pharmacist recommendations were implemented in 74% of cases, enhancing care quality and safety.

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    Area of Science:

    • Pharmacotherapy
    • Primary Care Medicine
    • Health Informatics

    Background:

    • Primary care lacks clinical pharmacists, hindering medication outcome management.
    • eConsult services offer a solution for primary care providers (PCPs) to access pharmacotherapy specialists.
    • Integrating clinical pharmacists into eConsult networks addresses a critical gap in medication management.

    Purpose of the Study:

    • To assess the utilization of clinical pharmacists within an established eConsult network.
    • To characterize the types and usage patterns of pharmacist eConsults initiated by PCPs.
    • To measure the rate of implementation of pharmacist recommendations by PCPs.

    Main Methods:

    • A federally qualified health center implemented a pharmacist eConsult service via an existing platform.
    • A clinical pharmacist responded to eConsults within two business days.
    • PCPs received training on the service, including suitable topics and workflow.

    Main Results:

    • 57 eConsults with 123 questions were addressed; Advanced Practice Registered Nurses (APRNs) submitted significantly more eConsults than physicians.
    • APRNs' queries focused on adverse drug events and dosage adjustments, while physicians sought medication regimen reviews and patient-specific adjustments.
    • PCPs implemented at least 50% of pharmacist recommendations in 74% of responses.

    Conclusions:

    • Pharmacist eConsults are a viable service for addressing medication-related questions in primary care.
    • This model can enhance prescribing quality and safety, particularly for chronic medication management.
    • Integrating pharmacists into eConsult networks supports value-based care initiatives.