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TFEB: A Emerging Regulator in Lipid Homeostasis for Atherosclerosis

Manman Li1, Zitong Wang1, Pengyu Wang1

  • 1Department of Pathophysiology, School of Basic Medical Sciences, Harbin Medical University, Harbin, China.

Frontiers in Physiology
|March 8, 2021
PubMed

Insights

Transcription factor EB (TFEB) plays a key role in regulating lipid metabolism and homeostasis. Targeting TFEB offers a promising therapeutic strategy for atherosclerosis, a condition marked by lipid imbalance.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cardiovascular Research

Background:

  • Atherosclerosis, a primary cause of cardiovascular disease, stems from disrupted lipid homeostasis.
  • Effective lipid modulators are crucial for managing atherosclerosis.
  • Transcription factor EB (TFEB) is a key regulator of cellular physiology, influenced by post-translational modifications.

Purpose of the Study:

  • To review current advances on TFEB's role in lipid metabolism and its therapeutic potential for atherosclerosis.
  • To explore how external stimuli modulate TFEB function and how TFEB restores lipid homeostasis in atherosclerosis.

Main Methods:

  • Literature review focusing on TFEB's involvement in lipid metabolism.
  • Analysis of TFEB's regulatory effects on lipophagy, lipolysis, and lipid metabolism-related genes.
  • Examination of TFEB's influence on lipid transporters and mediators.

Main Results:

  • TFEB promotes lipid degradation and efflux, crucial for maintaining lipid homeostasis.
  • Evidence suggests TFEB regulates lipid metabolism-related genes, lipophagy, and lipolysis.
  • TFEB influences lipid transporters and mediators, highlighting its broad impact on lipid regulation.

Conclusions:

  • TFEB is a significant regulator of lipid homeostasis and a potential therapeutic target for atherosclerosis.
  • Understanding TFEB's response to cellular stimuli is key to leveraging its therapeutic benefits.
  • Further research into TFEB-targeting agents is warranted to combat atherosclerosis progression.
Keywords:
TFEBatherosclerosislipid homeostasislipid mediatorslipid transporterslipophagypost-translational modifications

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