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Functions of Thyroid Hormones

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Synthesis and Regulation of Thyroid Hormones

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Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

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Thyroid Function Abnormalities in COVID-19 Patients.

Weibin Wang¹, Xingyun Su², Yongfeng Ding²

¹Department of Surgical Oncology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Frontiers in Endocrinology

|March 8, 2021

Summary

COVID-19 significantly impacts thyroid function, with lower thyroid stimulating hormone (TSH) and total triiodothyronine (TT3) observed in patients. Thyroid dysfunction is common, particularly in severe COVID-19 cases.

Keywords:

COVID-19 abnormality pathogenesis thyroid function thyroid stimulating hormone

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Area of Science:

Endocrinology
Infectious Diseases
Virology

Background:

The COVID-19 pandemic has led to widespread organ impairment.
The effect of COVID-19 on human thyroid function has not been previously established.

Purpose of the Study:

To investigate the prevalence and characteristics of thyroid function abnormalities in hospitalized COVID-19 patients.

Main Methods:

Retrospective analysis of 84 COVID-19 patients, 91 pneumonia patients, and 807 healthy controls.
Measurement of thyroid hormones including total triiodothyronine (TT3) and thyroid stimulating hormone (TSH).

Main Results:

COVID-19 patients exhibited lower TT3 and TSH levels compared to healthy controls.
Thyroid function abnormalities were present in 61.9% of COVID-19 patients, more frequent in severe cases.
Thyroid dysfunction correlated with prolonged viral clearance, decreased lymphocytes, and elevated C-reactive protein (CRP).

Conclusions:

Thyroid function abnormalities are common in COVID-19, especially in severe cases.
Nonthyroidal illness syndrome may contribute to these thyroid changes.