Correlation between optic disc deformation and retinal vasculature in non-pathological high myopia

Area of Science:

• Ophthalmology
• Retinal Imaging
• Vascular Biology

Background:

• High myopia is associated with structural changes in the optic nerve head and retina.
• Understanding the relationship between optic disc morphology and retinal vasculature is crucial for managing high myopia complications.

Purpose of the Study:

• To investigate the correlation between optic disc deformation and retinal vasculature in non-pathological high myopia.
• To determine if optic disc parameters can predict retinal microvascular changes.

Main Methods:

• Cross-sectional study of 130 eyes with high myopia.
• Analysis of optic disc parameters (β-zone parapapillary atrophy, tilt ratio, diameters) using fundus photography.
• Optical coherence tomography angiography used to assess vessel flow density (VFD), fractal dimension, and foveal avascular zone (FAZ).

Main Results:

• β-zone parapapillary atrophy showed a negative correlation with VFD in superficial and deep retinal plexuses, and radial peripapillary capillaries.
• Optic disc tilt ratio was negatively correlated with deep retinal layer vasculature.
• Age was negatively correlated with retinal VFD; FAZ showed no significant correlation.

Conclusions:

• Optic disc deformation is negatively correlated with retinal microvasculature in high myopia.
• Radial peripapillary capillaries and deep retinal plexus are particularly affected by optic disc deformation.
• Optic disc deformation may serve as a predictive marker for retinal vasculature in high myopia.