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Attention-deficit/hyperactivity disorder and brain metabolites from proton magnetic resonance spectroscopy: a
Marcos Vinícius Vidor1,2, Alana Castro Panzenhagen1,3, Alexandre Ribeiro Martins4
1Programa de Transtornos de Déficit de Atenção/Hiperatividade em Adultos (ProDAH-A), Centro de Pesquisa Clínica (CPC), Hospital de Clínicas de Porto Alegre (HCPA), Porto Alegre , RS , Brazil .
Abstract:
Despite major advances in the study of the brain, investigations on neurochemistry in vivo still lack the solid ground of more established methods, such as structural and functional magnetic resonance imaging. Proton magnetic resonance spectroscopy (MRS) is a technique that might potentially fill in this gap. Nevertheless, studies using this approach feature great methodological heterogeneity, such as varying voxel of choice, differences on emphasized metabolites, and absence of a standardized unit. In this study, we present a methodology for creating a systematic review and meta-analysis for this kind of scientific evidence using the prototypical case of attention-deficit/hyperactivity disorder. Systematic review registration: International Prospective Register of Systematic Reviews (PROSPERO), CRD42018112418.
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