Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

3.5K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
3.5K
Gross Anatomy of Bone01:17

Gross Anatomy of Bone

8.0K
The two main features of a long bone are the diaphysis and the epiphysis.
The diaphysis is the tubular shaft that runs between the proximal and distal ends of the bone. The walls of the diaphysis are composed of dense and hard compact bone made of numerous osteons — the functional unit of the compact bone. The hollow region in the diaphysis is called the medullary cavity, which harbors the bone marrow. In infants and children, this marrow cavity is filled with red marrow, whereas in...
8.0K
Compact Bone01:27

Compact Bone

15.0K
Most bones contain compact and spongy osseous tissue, but their distribution and concentration vary based on the bone's overall function.
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...
15.0K
Spongy Bone01:09

Spongy Bone

6.7K
All bones comprise an outer layer of compact bone, and an interior made up of spongy bone tissue, also called cancellous or trabecular bone. In long bones, spongy bone tissue is mainly found in the interior of the epiphyses (broad ends of the bone).
Spongy bone is more porous, and less dense compared to compact bone. It is composed of concentric lamellae that are arranged irregularly to form the trabecular network. In some bones, the spaces between trabeculae contain red marrow, where...
6.7K
Bone Disorders01:29

Bone Disorders

4.8K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
4.8K
Bone Formation by Intramembranous Ossification01:29

Bone Formation by Intramembranous Ossification

9.1K
Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into ...
9.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of Hyperbaric Oxygen Therapy on Early MRI-Based Graft Healing Following ACL Reconstruction With Hamstring Autografts.

Orthopaedic journal of sports medicine·2026
Same author

Distal Tibiofibular Syndesmosis: Anatomy, Biomechanics, Imaging Approach, and Postoperative Evaluation.

Radiographics : a review publication of the Radiological Society of North America, Inc·2026
Same author

Comprehensive Imaging Review of Osseous Metaphyseal Lesions.

Radiographics : a review publication of the Radiological Society of North America, Inc·2025
Same author

Diagnostic Imaging in Tennis: Epidemiology, Biomechanics, and Radiologic Spectrum of Injuries.

Seminars in musculoskeletal radiology·2025
Same author

Hip Microinstability: New Concepts and Comprehensive Imaging Evaluation.

Radiographics : a review publication of the Radiological Society of North America, Inc·2025
Same author

Whole-body Magnetic Resonance Imaging in Inflammatory Spine and Joint Disease.

Seminars in musculoskeletal radiology·2025

Related Experiment Video

Updated: Nov 14, 2025

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
08:07

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Published on: April 12, 2019

7.4K

Osteoid osteoma: the great mimicker.

Bruno C Carneiro1, Isabela A N Da Cruz2, Alípio G Ormond Filho1

  • 1Department of Musculoskeletal Radiology, Fleury Medicina e Saúde Higienópolis, Rua Mato Grosso 306, 1st Floor, Higienópolis, São Paulo, SP, 01239-040, Brazil.

Insights Into Imaging
|March 8, 2021
PubMed
Summary

Osteoid osteoma, a common benign bone tumor in young adults, presents with characteristic night pain relieved by NSAIDs. Accurate diagnosis relies on understanding typical and atypical imaging findings to avoid misdiagnosis.

Keywords:
Bone neoplasmsDiagnosisDifferentialMagnetic resonance imagingOsteoidOsteomaTomographyX-ray computed

More Related Videos

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone
06:53

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone

Published on: September 9, 2020

3.0K
Modeling Osteosarcoma Using Li-Fraumeni Syndrome Patient-derived Induced Pluripotent Stem Cells
08:52

Modeling Osteosarcoma Using Li-Fraumeni Syndrome Patient-derived Induced Pluripotent Stem Cells

Published on: June 13, 2018

9.1K

Related Experiment Videos

Last Updated: Nov 14, 2025

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
08:07

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Published on: April 12, 2019

7.4K
Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone
06:53

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone

Published on: September 9, 2020

3.0K
Modeling Osteosarcoma Using Li-Fraumeni Syndrome Patient-derived Induced Pluripotent Stem Cells
08:52

Modeling Osteosarcoma Using Li-Fraumeni Syndrome Patient-derived Induced Pluripotent Stem Cells

Published on: June 13, 2018

9.1K

Area of Science:

  • Orthopedics
  • Radiology
  • Oncology

Background:

  • Osteoid osteoma is a common, benign bone tumor primarily affecting young adults.
  • Characterized by nocturnal pain relieved by nonsteroidal anti-inflammatory drugs (NSAIDs).
  • Typical imaging reveals a nidus with sclerosis, cortical thickening, and edema.

Purpose of the Study:

  • To highlight the diagnostic challenges of osteoid osteoma.
  • To emphasize the importance of recognizing atypical presentations.
  • To improve diagnostic accuracy and patient outcomes.

Main Methods:

  • Review of clinical and radiological features of osteoid osteoma.
  • Analysis of typical and atypical lesion presentations.
  • Comparison with conditions that mimic osteoid osteoma.

Main Results:

  • Typical osteoid osteoma has characteristic clinical and imaging findings.
  • Atypical presentations include intraarticular, epiphyseal, and extremity locations.
  • Misdiagnosis can occur due to varied presentations and mimics.

Conclusions:

  • Understanding diverse presentations is crucial for accurate osteoid osteoma diagnosis.
  • Radiological interpretation and clinical correlation are essential.
  • Early diagnosis and treatment prevent poor prognosis.