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In Vitro Clot Trapping Efficiency of the FDA Generic Inferior Vena Cava Filter in an Anatomical Model: An
J M Riley1, N S Price1, H M Saaid1
1Department of Biomedical Engineering, The Pennsylvania State University, 122 Chemical and Biomedical Engineering Building, University Park, PA, 16802, USA.
Cardiovascular Engineering and Technology
|March 8, 2021
Summary
This study evaluated inferior vena cava (IVC) filter clot trapping efficiency. Clot size and origin significantly impact trapping, with larger clots and left iliac vein injections showing higher efficiencies.
Area of Science:
- Biomedical Engineering
- Fluid Dynamics
- Medical Devices
Background:
- Lack of experimental data for validating fluid-structure interaction (FSI) simulations of deformable solids in internal flow.
- Need for characterizing inferior vena cava (IVC) filter performance in trapping embolic materials.
Purpose of the Study:
- To experimentally characterize the clot trapping efficiency of a novel generic conical-type IVC filter.
- To provide robust data for validating FSI simulations in internal flow scenarios.
Main Methods:
- In vitro study using a rigid anatomical IVC model.
- Injection of various synthetic and blood clots (spherical, cylindrical) under exercise flow conditions.
- Quantification of clot trapping efficiencies and uncertainties based on clot properties and origin.
Main Results:
- Clot trapping efficiency increases with clot diameter and length (42% to 100%).
- Iliac vein of origin significantly influences trapping due to IVC model asymmetry (left vs. right iliac vein: ~10% vs. ~75%).
Conclusions:
- The generated dataset serves as a benchmark for validating IVC filter simulation models.
- Provides valuable data for low-Reynolds number FSI modeling of deformable body transport.
