Related Experiment Video
Updated: Nov 14, 2025
05:32
Author Spotlight: Assessing Ischemic Stroke Damage Through Middle Cerebral Artery Occlusion Model
Published on: August 11, 2023
2.5K
Wake-up stroke is not associated with obstructive sleep apnea.
Sonja G Schütz1, Lynda D Lisabeth2, River Gibbs3
1Sleep Disorders Center, Department of Neurology, University of Michigan, 1500 E. Medical Center Drive, Ann Arbor, MI 48109, USA.
Sleep Medicine
|March 8, 2021
Summary
Obstructive sleep apnea (OSA) is a known stroke risk factor. However, this study found no association between OSA and wake-up strokes (WUS) in a large population-based cohort.
Area of Science:
- Neurology
- Sleep Medicine
- Cardiovascular Research
Background:
- Obstructive sleep apnea (OSA) is a recognized risk factor for cerebrovascular events.
- Wake-up stroke (WUS) describes strokes where symptoms are first noticed upon awakening.
Purpose of the Study:
- To investigate the association between obstructive sleep apnea (OSA) and wake-up strokes (WUS).
- To determine if OSA severity influences the likelihood of stroke onset during sleep.
Main Methods:
- Utilized data from 837 participants in the Brain Attack Surveillance in Corpus Christi (BASIC) project.
- Assessed stroke onset timing (WUS vs. non-WUS) via interviews.
- Conducted home sleep apnea tests (HSAT) on 316 participants to diagnose and assess OSA severity.
- Employed regression models, stratified by sex, to analyze the relationship between OSA and WUS.
Main Results:
- Out of 837 participants, 30% reported WUS.
- No significant difference in OSA severity (Respiratory Event Index) was observed between WUS and non-WUS groups.
- OSA severity was not significantly associated with an increased odds of WUS in men or women, even after adjusting for confounding factors.
Conclusions:
- Despite OSA being a stroke risk factor, this study did not find a link between OSA and the occurrence of wake-up strokes.
- The findings suggest that stroke onset during sleep is not specifically associated with obstructive sleep apnea in this population.
Keywords:
Home sleep apnea testIschemic strokeObstructive sleep apneaSleep-disordered breathingWake-up strokeMore Related Videos
Related Concept Videos
01:21Sleep Apnea
299
Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
The condition is more prevalent among...
299
01:24Sleep-Wake Cycles
2.3K
Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
2.3K
01:27Regulation of Stroke Volume
4.4K
The regulation of stroke volume, which is the amount of blood the heart pumps out during each heartbeat, is critical for maintaining a healthy circulatory system. Stroke volume is influenced by three main factors: preload, contractility, and afterload.
Preload refers to the degree of stretch on the heart before it contracts. It's analogous to the stretching of a rubber band; the more it's stretched, the more forcefully it snaps back. This concept is encapsulated in the Frank-Starling law of the...
Preload refers to the degree of stretch on the heart before it contracts. It's analogous to the stretching of a rubber band; the more it's stretched, the more forcefully it snaps back. This concept is encapsulated in the Frank-Starling law of the...
4.4K
01:15REM Sleep Behavior Disorder
784
REM Sleep Behavior Disorder (RBD) is a sleep disorder characterized by the absence of muscle paralysis that normally occurs during the REM phase of sleep. This absence allows individuals to physically act out their dreams, which are often vivid and disturbing. Common behaviors exhibited during episodes include kicking, punching, and yelling. These actions can be dangerous, potentially leading to injuries for the person with RBD or their bed partner.
RBD is significantly associated with...
RBD is significantly associated with...
784
01:17Sleepwalking and Sleep Talking
472
Somnambulism, commonly known as sleepwalking, involves individuals engaging in activities ranging from simple walking to more complex behaviors such as driving. Sleepwalking typically occurs during the slow-wave sleep stages 3 and 4 early in the night when the person is not dreaming, contradicting the myth that sleepwalkers are acting out their dreams.
Factors that increase the likelihood of sleepwalking include sleep deprivation and alcohol consumption. Contrary to common beliefs, it is safe...
Factors that increase the likelihood of sleepwalking include sleep deprivation and alcohol consumption. Contrary to common beliefs, it is safe...
472
01:22Stages of Sleep
938
Sleep progresses through distinct stages, each characterized by specific brain wave patterns and physiological responses ranging from wakefulness to stages of non-rapid eye movement, known as non-REM, to rapid eye movement, referred to as REM. Understanding these stages helps in recognizing how sleep supports various bodily and cognitive functions.
Before sleep begins, in wakefulness, the brain exhibits primarily beta waves, which are high in frequency and low in amplitude, indicating alertness...
Before sleep begins, in wakefulness, the brain exhibits primarily beta waves, which are high in frequency and low in amplitude, indicating alertness...
938