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Advancing Stroke Clinical Trials Using Community Engagement and Implementation Science Approaches
Lesli E Skolarus1, Devin L Brown2, Bernadette Boden-Albala3,4,5
1Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Annals of Clinical and Translational Neurology
|June 25, 2026
Summary
Integrating community engagement and implementation science into stroke clinical trials can enhance efficiency and relevance. This approach aims to improve trial outcomes and accelerate the translation of findings into real-world stroke care.
Area of Science:
- Neurology
- Public Health
- Implementation Science
Background:
- Stroke clinical trials are crucial for advancing stroke care.
- Challenges include recruitment, retention, clinical relevance, and real-world translation.
- Existing trial methodologies may not fully address these implementation barriers.
Purpose of the Study:
- To propose integrating community engagement and implementation science into stroke clinical trials.
- To address challenges in trial efficiency, relevance, and translation.
- To improve stroke health outcomes through better trial design and execution.
Main Methods:
- Conceptualizing clinical trials as an evidence-based practice.
- Utilizing implementation frameworks and strategies to identify and address trial determinants.
- Engaging diverse stakeholders throughout the trial lifecycle.
Main Results:
- Anticipating and addressing multilevel determinants of trial success.
- Facilitating negotiation of trade-offs and aligning trial decisions with stakeholder needs.
- Potential for improved trial efficiency and strengthened relevance.
Conclusions:
- Integrating community engagement and implementation science can enhance stroke trial efficiency and relevance.
- This approach accelerates the translation of research findings into practice.
- Ultimately, this integration aims to advance stroke health for all populations.
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