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Relationship Between Systemic Immune-Inflammation Index (SII) and the Severity of Stable Coronary Artery Disease

Mustafa Candemir1, Emrullah Kiziltunç1, Serdar Nurkoç2

  • 1Department of Cardiology, 64001Faculty of Medicine, Gazi University, Ankara, Turkey.

Angiology
|March 9, 2021
PubMed

Insights

The systemic immune-inflammation index (SII) is a novel marker that predicts coronary artery disease (CAD) severity. Higher SII levels correlate with more severe coronary atherosclerosis, aiding in risk assessment.

Area of Science:

  • Cardiology
  • Immunology
  • Biochemistry

Background:

  • Coronary artery disease (CAD) poses significant health risks.
  • Predictive markers for CAD severity are crucial for patient management.
  • The systemic immune-inflammation index (SII) is a novel marker derived from routine blood counts.

Purpose of the Study:

  • To investigate the association between the systemic immune-inflammation index (SII) and the severity of coronary artery disease (CAD).
  • To evaluate if SII provides more valuable information on CAD severity compared to other white blood cell-derived ratios.
  • To assess the predictive performance of SII for severe coronary lesions.

Main Methods:

  • Retrospective analysis of 669 patients undergoing coronary angiography.
  • Calculation of the Systemic Immune-Inflammation Index (SII) using platelet count and neutrophil-to-lymphocyte ratio.
  • Determination of coronary atherosclerosis severity using the SYNTAX score (SxS).
  • Multivariate logistic regression and correlation analyses were performed.

Main Results:

  • The SII was identified as an independent predictor of a high SYNTAX score (SxS) in patients with CAD (OR: 1.004, P = .015).
  • A significant positive correlation was observed between SII and SxS (Rho: 0.630, P ≤ .001).
  • Receiver-operating characteristic analysis indicated that an SII cutoff of 750 × 10³ predicted severe coronary lesions with 86.2% sensitivity and 87.3% specificity.

Conclusions:

  • The Systemic Immune-Inflammation Index (SII) is significantly associated with the severity of coronary artery disease (CAD) and high SYNTAX scores (SxS).
  • SII is a valuable, inexpensive, and easily measurable laboratory marker for assessing CAD severity in patients with stable angina.
  • SII may offer additional prognostic information beyond traditional risk factors in CAD assessment.

Keywords:
coronary artery diseasesyntax scoresystemic immune-inflammation index

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