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Combined manometric and radiological study of the changes in colonic motility induced by sennosides in rats
C Spiessens1, L Ceuterick, E Ponette
1Department of Pharmaceutical Biology and Phytopharmacology, K.U. Leuven, Belgium.
Pharmacology
|January 1, 1988
Abstract:
Colonic motility changes induced by sennosides in rats were studied by an original method, which permits the simultaneous projection of manometric and fluoroscopic registrations on a single monitor. The results of this study allowed us to confirm the laxative effect of sennosides by inducing mass movements within 60-80 min after intracecal administration leading to a complete emptying of the whole colon. These mass movements were preceded by hypotonia of cecum and colon and impeded pellet formation.