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'Desire for more analgesic treatment': pain and patient-reported outcome after paediatric tonsillectomy and
Ulrike M Stamer1, Kyra Bernhart2, Thomas Lehmann3
1Department of Anaesthesiology and Pain Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; Department of BioMedical Research, University of Bern, Bern, Switzerland.
Insights
Pain after paediatric surgery is common. Giving at least two types of non-opioid pain relievers before surgery can improve patient outcomes and reduce the need for more pain treatment.
Area of Science:
- Pediatric Surgery
- Pain Management
- Pharmacology
Background:
- Post-operative pain is frequent following paediatric appendectomy and tonsillectomy.
- Identifying factors associated with poor patient-reported pain outcomes is crucial.
Purpose of the Study:
- To identify variables linked to inadequate pain management after paediatric appendectomy and tonsillectomy.
- To analyze patient-reported outcomes and perioperative pharmacological data.
Main Methods:
- Analysis of data from the European PAIN OUT infant registry.
- Utilized elastic net regularization to evaluate variables associated with 'desire for more pain treatment'.
Main Results:
- 24.8% of appendectomy and 20.2% of tonsillectomy patients desired more pain treatment.
- Pain-related sleep disturbance and higher pain intensity increased the likelihood of desiring more treatment.
- Preventive administration of at least two non-opioid analgesic classes was inversely associated with the desire for more postoperative analgesics.
Conclusions:
- Preventive administration of multiple non-opioid analgesics is a simple strategy to enhance patient-reported outcomes.
- This approach may reduce the need for additional pain medication post-surgery.
Background:
Insufficiently treated pain after paediatric appendectomy and tonsillectomy is frequent. We aimed to identify variables associated with poor patient-reported outcomes.
Methods:
This analysis derives from the European PAIN OUT infant registry providing information on perioperative pharmacological data and patient-reported outcomes 24 h after surgery. Variables associated with the endpoint 'desire for more pain treatment' were evaluated by elastic net regularisation (odds ratio [95% confidence interval]).
Results:
Data from children undergoing appendectomy (n=472) and tonsillectomy (n=466) between 2015 and 2019 were analysed. Some 24.8% (appendectomy) and 20.2% (tonsillectomy) wished they had received more pain treatment in the 24 h after surgery. They reported higher composite pain scores (5.2 [4.8-5.5] vs 3.6 [3.5-3.8]), more pain-related interference, and more adverse events than children not desiring more pain treatment, and they received more opioids after surgery (morphine equivalents (81 [60-102] vs 50 [43-56] μg kg-1). Regression analysis revealed that pain-related sleep disturbance (appendectomy odds ratio: 2.8 [1.7-4.6], tonsillectomy 3.7 [2.1-6.5]; P<0.001) and higher pain intensities (1.5-fold increase) increased the probability of desiring more pain treatment. There was an inverse association between the number of different classes of non-opioids administered preventively, and the desire for more analgesics postoperatively. Children not receiving any non-opioid analgesics before the end of a tonsillectomy had a 3.5-fold (2.1-6.5-fold) increase in the probability of desiring more pain treatment, compared with children receiving at least two classes of different non-opioid analgesics.
Conclusions:
Preventive administration of at least two classes of non-opioid analgesics is a simple strategy and may improve patient-reported outcomes.
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