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Updated: Nov 14, 2025

Assessment of the Metabolic Effects of Isocaloric 2:1 Intermittent Fasting in Mice
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Intermittent fasting: from calories to time restriction.

Eleonora Duregon1, Laura C D D Pomatto-Watson1, Michel Bernier1

  • 1Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD, 21224, USA.

Geroscience
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Summary

Calorie restriction (CR) benefits metabolic health, but is hard to maintain. New intermittent fasting and time-restricted feeding strategies mimic CR

Keywords:
Calorie restrictionCaloriesFastingIntermittent FastingTime Restricted Feeding

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Area of Science:

  • Gerontology
  • Metabolic Health
  • Nutritional Science

Background:

  • Global life expectancy increases, raising concerns about age-associated chronic diseases and healthcare burdens.
  • Calorie restriction (CR) enhances longevity in model organisms but is difficult for humans to sustain.
  • Intermittent fasting (IF) and time-restricted feeding (TRF) show promise in mimicking CR benefits without strict adherence.

Purpose of the Study:

  • To review current knowledge on dietary strategies that confer CR-like metabolic health benefits.
  • To explore alternatives to continuous CR for human application.
  • To present findings from the USU State of the Science Symposium.

Main Methods:

  • Review of scientific literature on CR, IF, and TRF.
  • Analysis of studies in murine models and human subjects.
  • Synthesis of data presented at the USU State of the Science Symposium.

Main Results:

  • IF and TRF strategies can recapitulate many health benefits of CR.
  • These dietary patterns offer potential solutions for improving metabolic health without continuous caloric reduction.
  • Evidence from both animal models and human studies supports these findings.

Conclusions:

  • Novel feeding strategies like IF and TRF provide accessible means to achieve CR-associated metabolic health benefits.
  • These approaches offer a more practical alternative to traditional CR for long-term human health interventions.
  • Further research is warranted to optimize these strategies for diverse populations.