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Updated: Nov 14, 2025
A Unified Methodological Framework for Vestibular Schwannoma Research
Published on: June 20, 2017
Malignant vestibular schwannoma with intracerebral metastasis
Sayedeh Ameneh Salehi-Reyhani1, Gulam Zilani1, Alistair Lammie2
1Department of Neurosurgery, University Hospital of Wales, Cardiff, United Kingdom of Great Britain and Northern Ireland.
Background:
Malignant change in vestibular schwannoma is rare and intracranial metastatic deposits have not been reported.
Clinical Presentation:
We report the case of a 64 year old woman with a benign vestibular schwannoma who underwent translabyrinthine excision in 1996 and Gamma Knife® radiosurgery (Elekta AB, Stockholm, Sweden) (GKRS) in 2006. She presents 10 years after GKRS with progressive neurological deterioration. Histopathologic analysis confirms a malignant peripheral nerve sheath tumour, WHO grade IV with subsequent metastatic spread to the left thalamus confirmed on biopsy.
Conclusion:
We report a rare case of a vestibular schwannoma metastasizing with histological confirmation. It also reminds us of malignant conversion of a benign vestibular schwannoma following GKRS and subsequent aggressive behaviour, with poor prognosis.
