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Coagulopathy in COVID-19

Ka U Lio1, Parth Rali2

  • 1Medical student, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Lung India : Official Organ of Indian Chest Society
|March 9, 2021
PubMed

Insights

Severe COVID-19 is linked to hemostatic derangement, with elevated D-dimer and fibrinogen degradation products. Many nonsurvivors met criteria for disseminated intravascular coagulation (DIC), highlighting coagulation

Area of Science:

  • Coagulation and Thrombosis
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • Severe COVID-19 presents with significant hemostatic abnormalities.
  • Elevated D-dimer and fibrinogen degradation products are common in severe cases.
  • Disseminated intravascular coagulation (DIC) affects a high percentage of non-survivors.

Purpose of the Study:

  • To review the role of hemostasis in COVID-19 pathogenesis.
  • To evaluate the impact of hemostatic derangements on disease severity.
  • To discuss hemostasis in the management of COVID-19.

Main Methods:

  • Literature review of studies on COVID-19 and hemostasis.
  • Analysis of clinical data regarding coagulation markers.
  • Evaluation of diagnostic criteria for DIC in COVID-19 patients.

Main Results:

  • Hemostatic derangement is a key feature of severe COVID-19.
  • High prevalence of elevated coagulation markers and DIC in non-survivors.
  • Coagulation abnormalities contribute to COVID-19 severity.

Conclusions:

  • Understanding hemostasis is crucial for managing severe COVID-19.
  • Targeting coagulation pathways may be essential for improving patient outcomes.
  • Further research into COVID-19-associated coagulopathy is warranted.

Keywords:
Acute respiratory distress syndromeCOVID-19D-dimeranticoagulantcoagulopathydisseminated intravascular coagulopathyheparin

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