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Detecting DPD deficiency: when perfect is the enemy of good

Joseph Ciccolini1, Gérard Milano2, Henk-Jan Guchelaar3

  • 1SMARTc Unit, CRCM Inserm U1068 and Clinical Pharmacokinetics Lab, La Timone Hospital University of Marseille, Marseille, France. ciccolini.joseph@gmail.com.

Cancer Chemotherapy and Pharmacology
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PubMed
Abstract

No abstract available in PubMed .

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Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
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