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Related Concept Videos

Stem Cell Culture01:17

Stem Cell Culture

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

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Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
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iPS Cell Differentiation01:22

iPS Cell Differentiation

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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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Embryonic Stem Cells00:58

Embryonic Stem Cells

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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Pluripotent Stem Cell Derived Cardiac Cells for Myocardial Repair
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Pluripotent Stem Cells for Cell Therapy.

Insa S Schroeder1

  • 1Stem Cell Differentiation and Cytogenetics Group, Biophysics Department, GSI Helmholtz Center for Heavy Ion Research, Darmstadt, Germany. i.schroeder@gsi.de.

Methods in Molecular Biology (Clifton, N.J.)
|March 9, 2021
PubMed
Summary
This summary is machine-generated.

Pluripotent stem cells, including induced pluripotent stem cells, are vital for regenerative medicine and disease research. Despite challenges in cell maturation and integration, they offer significant potential for treating age-related diseases.

Keywords:
Cell therapyClinical translationDifferentiationEmbryonic stem cellsInduced pluripotent stem cells

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Area of Science:

  • Regenerative Medicine
  • Stem Cell Biology
  • Geriatric Medicine

Background:

  • Aging populations face increasing chronic and degenerative diseases.
  • Current cell therapies often use adult stem cells.
  • Pluripotent stem cells offer versatile regenerative potential.

Purpose of the Study:

  • Explore novel regenerative medicine approaches using pluripotent stem cells.
  • Investigate the utility of induced pluripotent stem cells (iPSCs) alongside embryonic stem cells.
  • Highlight the role of stem cells in disease modeling and drug discovery.

Main Methods:

  • Utilizing pluripotent stem cells (embryonic and induced) for differentiation.
  • Employing targeted genome engineering for disease modeling.
  • Scaling cell production for clinical applications.

Main Results:

  • Pluripotent stem cells demonstrate capacity for indefinite growth and differentiation.
  • Induced pluripotent stem cells expand the range of patient-specific cell models.
  • Genome engineering facilitates disease modeling and therapeutic development.

Conclusions:

  • Pluripotent stem cells are crucial for advancing regenerative medicine.
  • Challenges remain in achieving sufficient cell maturation and in vivo integration.
  • These cells are invaluable for understanding disease and developing new treatments.