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Updated: Nov 14, 2025
11:12
Optimization of a Multiplex RNA-based Expression Assay Using Breast Cancer Archival Material
Published on: August 1, 2018
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FOXQ1 is Differentially Expressed Across Breast Cancer Subtypes with Low Expression Associated with Poor Overall
Fahed A Elian1, Ubah Are1, Sunita Ghosh2,3
1Department of Medical Genetics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.
Breast Cancer (Dove Medical Press)
|March 10, 2021
Summary
Low Forkhead box Q1 (FOXQ1) mRNA expression indicates poor prognosis in breast cancer (BC) patients. This study evaluated FOXQ1
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Forkhead box Q1 (FOXQ1) role in cancer development, including breast cancer (BC).
- Limited research on FOXQ1 expression, copy number variation (CNV), and prognostic value across BC subtypes.
Purpose of the Study:
- Evaluate FOXQ1 mRNA expression, CNV, and prognostic value in different BC subtypes.
- Investigate the relationship between FOXQ1 expression and BC patient outcomes.
Main Methods:
- Quantified FOXQ1 mRNA expression and CNV in BC tumors (RT-qPCR, qPCR).
- Analyzed FOXQ1 expression and CNV in BC cell lines (CCLE database, K-means clustering).
- Assessed prognostic value using TCGA-BRCA database (Cox's regression, OncoLnc, GEPIA, UALCAN).
Main Results:
- FOXQ1 mRNA is differentially expressed across BC subtypes, decreased in luminal BC and HER2+.
- FOXQ1 mRNA expression was independent of CNV in BC cell lines.
- Low FOXQ1 mRNA expression correlated with significantly poorer overall survival.
- Low FOXQ1 expression independently predicted overall survival, adjusted for BC subtypes and other FOX genes (FOXF2, FOXM1).
Conclusions:
- FOXQ1 is differentially expressed across breast cancer subtypes.
- Low FOXQ1 expression is a significant indicator of poor prognosis in breast cancer patients.
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