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Updated: Nov 14, 2025
Cerebrovascular Casting of the Adult Mouse for 3D Imaging and Morphological Analysis
Published on: November 30, 2011
Cerebrovascular development: mechanisms and experimental approaches
Timothy J A Chico1,2,3, Elisabeth C Kugler4,5,6
1Department of Infection, Immunity and Cardiovascular Disease, Medical School, University of Sheffield, Beech Hill Road, Sheffield, S10 2RX, UK. t.j.chico@sheffield.ac.uk.
Abstract:
The cerebral vasculature plays a central role in human health and disease and possesses several unique anatomic, functional and molecular characteristics. Despite their importance, the mechanisms that determine cerebrovascular development are less well studied than other vascular territories. This is in part due to limitations of existing models and techniques for visualisation and manipulation of the cerebral vasculature. In this review we summarise the experimental approaches used to study the cerebral vessels and the mechanisms that contribute to their development.
