Related Experiment Video

Updated: Jun 23, 2026

Invasive Hemodynamic Characterization of the Portal-hypertensive Syndrome in Cirrhotic Rats
09:37

Invasive Hemodynamic Characterization of the Portal-hypertensive Syndrome in Cirrhotic Rats

Published on: August 1, 2018

15.2K

Review article: comprehensive analysis of cirrhotic cardiomyopathy

Daljeet Chahal1, Hongqun Liu2, Chris Shamatutu3

  • 1Division of Gastroenterology, University of British Columbia, Vancouver, BC, Canada.

Alimentary Pharmacology & Therapeutics
|March 10, 2021
PubMed

Insights

Cirrhotic cardiomyopathy, a heart condition in cirrhosis patients, presents unique challenges. This review covers its definition, causes, diagnosis, and impact on liver transplantation, highlighting its clinical relevance.

Area of Science:

  • Cardiology
  • Hepatology
  • Internal Medicine

Background:

  • Cirrhosis patients face risks of developing cirrhotic cardiomyopathy.
  • This syndrome involves subnormal cardiac function without prior heart disease.
  • No comprehensive review of cirrhotic cardiomyopathy currently exists.

Purpose of the Study:

  • To conduct a comprehensive literature review on cirrhotic cardiomyopathy.
  • To cover its definition, pathogenesis, diagnostic criteria, prevalence, management, and impact on liver transplantation.
  • To investigate the reversibility of cirrhotic cardiomyopathy post-transplantation.

Main Methods:

  • Searched EMBASE, MEDLINE, Cochrane Library, and Google Scholar databases.
  • Utilized MeSH terms related to cirrhosis, cardiomyopathy, medications, and epidemiology.
  • Reviewed literature published up to August 2020.

Main Results:

  • New diagnostic criteria for cirrhotic cardiomyopathy include echocardiographic systolic and diastolic dysfunction.
  • Pathogenesis is linked to the inflammatory phenotype of cirrhosis; prevalence ranges from 26-81%.
  • Medical therapies lack clear efficacy; the condition increases post-transplant cardiovascular event risk, with controversial reversibility.

Conclusions:

  • Cirrhotic cardiomyopathy significantly impacts patient morbidity and mortality.
  • It is a clinically relevant condition requiring further research and management strategies.
  • Understanding and managing cirrhotic cardiomyopathy is crucial for improving outcomes in cirrhosis patients.
Abstract

More Related Videos

Isolation and Characterization of Cardiac Mesenchymal Stromal Cells from Endomyocardial Bioptic Samples of Arrhythmogenic Cardiomyopathy Patients09:16

Isolation and Characterization of Cardiac Mesenchymal Stromal Cells from Endomyocardial Bioptic Samples of Arrhythmogenic Cardiomyopathy Patients

Published on: February 28, 2018

7.9K
Assessing Cardiac Reprogramming using High Content Imaging Analysis06:02

Assessing Cardiac Reprogramming using High Content Imaging Analysis

Published on: October 26, 2020

1.4K

Related Concept Videos

Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
Cirrhosis I: Introduction01:23

Cirrhosis I: Introduction

Cirrhosis is a chronic, irreversible liver disease characterized by the widespread replacement of healthy liver tissue with fibrotic scar tissue and the formation of regenerative nodules.Etiology of cirrhosisCirrhosis results from sustained liver injury that triggers progressive fibrosis and structural remodeling. The underlying causes are diverse, encompassing common and less frequent clinical conditions. Regardless of the origin, all causes lead to chronic inflammation, hepatocyte loss, and...
Cirrhosis II: Pathophysiology01:24

Cirrhosis II: Pathophysiology

Cirrhosis is a progressive chronic liver injury caused by prolonged inflammation, excessive fibrotic remodeling, and impaired regeneration. Over time, repeated hepatic insults disrupt the liver’s architecture and function, leading to reduced blood flow, impaired bile drainage, and diminished metabolic capacity.Pathophysiology of cirrhosisCirrhosis arises from three main responses to chronic liver damage: inflammation, immune activation, and hepatocyte death. These processes lead to structural...