Related Experiment Video
Updated: Nov 14, 2025
08:41
Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
Published on: November 5, 2021
3.1K
SARS-CoV-2 and pediatric solid organ transplantation: Current knowns and unknowns
Arnaud G L'Huillier1, Lara Danziger-Isakov2, Abanti Chaudhuri3
1Pediatric Infectious Diseases Unit, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland.
Pediatric Transplantation
|March 10, 2021
Summary
This expert opinion document addresses COVID-19 in pediatric solid organ transplant (SOT) recipients, offering guidance on prevention, diagnosis, and management. It highlights knowledge gaps for future research in this vulnerable population.
Area of Science:
- Pediatric Infectious Diseases
- Transplant Medicine
- Virology
Background:
- The COVID-19 pandemic presents unique challenges for pediatric solid organ transplant (SOT) candidates and recipients.
- Existing data on SARS-CoV-2 in this population are limited, necessitating expert guidance.
Observation:
- Clinical presentation, prevention, diagnosis, and management of SARS-CoV-2 infection require specific considerations in pediatric SOT patients.
- Expert opinion synthesizes current data from adult SOT and general pediatric populations to inform pediatric SOT care.
Findings:
- This document provides expert-derived recommendations for managing SARS-CoV-2 infection in pediatric SOT candidates and recipients.
- It addresses practical scenarios and frequently asked questions encountered in clinical settings.
- Key knowledge gaps requiring further investigation are identified.
Implications:
- The guidance aims to improve the care and outcomes for pediatric SOT recipients during the COVID-19 pandemic.
- It serves as a resource for clinicians managing these immunocompromised children.
- Further research is crucial to fill existing data voids in pediatric SOT and COVID-19.
Related Concept Videos
01:24Tissue Transplantation
700
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
700
01:28Kidney Transplant I: Introduction
147
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
147
01:26Kidney Transplant II: Surgical Procedure
140
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
140
01:03Rous Sarcoma Virus (RSV) and Cancer
5.8K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
5.8K
01:22Bone Marrow Sampling and Transplants
634
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
634
01:23Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption
94
Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
94