[Connective tissue disease-related interstitial lung disease]

Area of Science:

• Rheumatology
• Pulmonology
• Immunology

Background:

• Connective tissue diseases (CTDs) are autoimmune disorders affecting multiple organs.
• Interstitial lung disease (ILD) is a frequent complication of CTDs.
• Nonspecific interstitial pneumonia (NSIP) and usual interstitial pneumonia (UIP) are the most common ILD patterns in CTDs.

Purpose of the Study:

• To present a screening and treatment algorithm for ILD in systemic sclerosis.
• To discuss the management of ILD in rheumatoid arthritis.
• To provide an overview of ILD screening and treatment in CTDs.

Main Methods:

• High-resolution chest computed tomography (CT) is the preferred screening method for ILD.
• Treatment strategies include glucocorticoids, immunosuppressive agents, antifibrotic drugs, and non-pharmacological therapies.
• Established algorithms guide ILD management in systemic sclerosis.

Main Results:

• Systemic sclerosis has a well-established ILD screening and treatment algorithm.
• Rheumatoid arthritis management for ILD is discussed due to its prevalence and public interest.
• A comprehensive approach to ILD in CTDs is outlined.

Conclusions:

• ILD is a significant pulmonary manifestation of CTDs requiring specific screening and management.
• Tailored treatment algorithms, incorporating pharmacological and non-pharmacological approaches, are crucial for managing ILD in CTDs.
• Early detection and appropriate treatment of ILD in CTDs can improve patient outcomes.