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Bioavailability Enhancement: Drug Permeability Enhancement

Bioavailability Enhancement: Drug Permeability Enhancement

Body:After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt...

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

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Body:Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...

Bioavailability Enhancement: Drug Solubility Enhancement

Bioavailability Enhancement: Drug Solubility Enhancement

Body:Bioavailability is a critical factor in determining a drug's effectiveness. It refers to the proportion of a drug that enters the circulation when introduced into the body and is, as a result, able to have an active effect. Enhancing bioavailability is essential for drugs with poor solubility, as it can significantly impact their therapeutic efficacy. Various methods are employed to increase the solubility of drugs, thereby enhancing their bioavailability.Micronization and nanonization are...

Drug Delivery: Miscellaneous Routes

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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...

Drug Delivery: Overview

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The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...

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Updated: Nov 14, 2025

Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells

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Published on: February 9, 2019

An efficient approach for development and optimisation of curcumin-loaded solid lipid nanoparticles' patch for

Fakhara Sabir^1,2, Maimoona Qindeel^1,3, Asim Ur Rehman¹

¹Department of Pharmacy, Quaid-i-Azam University, Islamabad, Pakistan.

Journal of Microencapsulation

|March 10, 2021

Summary

This study developed an optimized Curcumin-loaded Solid Lipid Nanoparticles (C-SLNs) patch for transdermal delivery. The novel approach resulted in enhanced skin permeation, offering a simple and effective drug delivery system.

Keywords:

Curcumin PVA Permeability injection method patch solid lipid nanoparticles transdermal drug delivery

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Area of Science:

Pharmaceutical Sciences
Materials Science
Drug Delivery

Background:

Transdermal drug delivery offers advantages over oral administration.
Developing effective formulations for poorly soluble drugs like curcumin is challenging.
Solid Lipid Nanoparticles (SLNs) show promise for enhancing drug bioavailability.

Purpose of the Study:

To develop and optimize a Curcumin-loaded Solid Lipid Nanoparticles (C-SLNs) patch for transdermal delivery.
To evaluate the physicochemical properties, in vitro release, and ex vivo skin permeation of the C-SLNs patch.
To assess the efficacy of a permeation enhancer in the transdermal patch.

Main Methods:

Curcumin-loaded SLNs (C-SLNs) were optimized using response surface central composite design and a modified injection method.
Optimized C-SLNs were incorporated into a polyvinyl alcohol-based patch via the backing membrane method.
Compatibility (FTIR, XRPD), in vitro release, ex vivo skin permeation, stability, and evaluation studies were conducted.

Main Results:

Optimized C-SLNs exhibited a particle diameter of 170 ± 2 nm and high encapsulation efficiency (90 ± 3.5%).
Scanning Electron Microscopy (SEM) confirmed the spherical morphology of the nanoparticles.
The C-SLNs patch demonstrated sustained release for up to 72 hours.
A 6.5-fold enhancement in skin permeation was observed with the use of a permeation enhancer (PE).

Conclusions:

The modified injection method is a simple, economical, and time-efficient approach for developing C-SLNs patches.
The developed C-SLNs patch is a promising system for effective transdermal delivery of curcumin.
The inclusion of a permeation enhancer significantly improves the transdermal permeation of curcumin.