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Ultrasonic Assessment of Myocardial Microstructure

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Novel Methodology for Measuring Regional Myocardial Efficiency.

Grant T Gullberg, Uttam M Shrestha, Alexander I Veress

IEEE Transactions on Medical Imaging

|March 10, 2021

Summary

This study introduces a novel PET/MRI method to precisely measure cardiac efficiency in small tissue segments, calculating myocardial oxygen consumption and work to determine efficiency. The new approach yields cardiac efficiency values ranging from 6 to 18%.

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In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography

In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography

Published on: February 16, 2016

Area of Science:

Cardiovascular Imaging
Biomedical Engineering
Nuclear Medicine

Background:

Traditional cardiac efficiency measures are global.
Assessing regional cardiac tissue efficiency is crucial for understanding heart function.
Advanced imaging techniques like PET/MRI offer potential for detailed analysis.

Purpose of the Study:

To develop and validate a novel PET/MRI approach for measuring regional cardiac efficiency.
To quantify myocardial oxygen consumption (MVO2) and myocardial equivalent minute work (MEMW) in specific cardiac tissue segments.
To calculate cardiac efficiency (MEMW/MVO2) at a segmental level.

Main Methods:

Dynamic cardiac PET/MRI using 11C-acetate for 25 minutes.
Construction of a patient-specific 3D finite element (FE) biomechanical heart model using MRI cine data.
Application of a 1-tissue compartment model to PET data for K1 (blood flow) and k2(mono) (MVO2) calculations.
Integration of FE model stress/strain data with PET-derived MVO2 to compute MEMW and segmental cardiac efficiency.

Main Results:

Global myocardial blood flow (MBF) was 0.96 ± 0.15 ml/min/gm.
Myocardial oxygen consumption (MVO2) ranged from 8 to 17 ml/100gm/min.
Segmental Myocardial Equivalent Minute Work (MEMW) ranged from 0.1 to 0.4 joules/gm/min, with Cardiac Efficiency between 6% and 18%.

Conclusions:

The developed PET/MRI method enables accurate, segmental measurement of cardiac efficiency.
This technique provides a more granular understanding of cardiac energy metabolism and mechanical function.
The findings highlight the potential of integrated imaging and modeling for personalized cardiovascular assessment.