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Related Concept Videos

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Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
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Updated: Nov 14, 2025

Visualization of Amyloid &#946; Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry
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Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry

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Functional amyloids in the human body.

Amy Brown1, Marianna Török1

  • 1Department of Chemistry, University of Massachusetts Boston, 100 Morrissey Blvd., Boston, MA 02125, USA.

Bioorganic & Medicinal Chemistry Letters
|March 10, 2021
PubMed
Summary
This summary is machine-generated.

Functional amyloids play vital roles in human biology, distinct from toxic amyloids implicated in disease. Understanding these differences offers new therapeutic avenues.

Keywords:
AmyloidDrug deliveryHormonePeptideSelf-assembly

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Area of Science:

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Background:

  • Amyloids are traditionally linked to human degenerative diseases.
  • Recent findings reveal functional amyloids exist in the human body.
  • These functional amyloids participate in diverse biological processes.

Purpose of the Study:

  • To survey the biological roles of functional amyloids.
  • To delineate key differences between functional and toxic amyloids.
  • To explore potential therapeutic applications of functional amyloids.

Main Methods:

  • Literature review and synthesis of existing research.
  • Comparative analysis of structural and kinetic properties.
  • Exploration of biological functions and disease associations.

Main Results:

  • Functional amyloids are involved in processes like hormone storage and necroptosis.
  • Distinct differences in assembly/disassembly kinetics and structure exist between functional and toxic amyloids.
  • Functional amyloids represent a distinct class with unique biological significance.

Conclusions:

  • Functional amyloids are integral to normal human physiology.
  • Distinguishing functional from toxic amyloids is crucial for therapeutic development.
  • Targeting functional amyloid pathways may offer novel treatment strategies.