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Related Experiment Videos

The Swann phenotype 700:4,-41; genetic studies.

M Lewis1, H Kaita, S Philipps

  • 1Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Canada.

Vox Sanguinis
|January 1, 1988
PubMed
Summary

The Swa antigen is not associated with several known blood group systems, including P1, Dombrock, and Yt. Linkage analysis further excluded close genetic links to numerous other blood group loci and a specific chromosome region.

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Area of Science:

  • Genetics
  • Immunology
  • Hematology

Background:

  • The Swa antigen is a red blood cell surface marker.
  • Its precise genetic location and association with established blood group systems were previously undetermined.

Purpose of the Study:

  • To determine the genetic linkage of the SW blood group locus.
  • To exclude the Swa antigen from known blood group systems and chromosomal locations.

Main Methods:

  • Serological analysis of red blood cells from a French-Canadian kindred.
  • Linkage analysis of the SW locus against 27 other genetic loci.

Main Results:

  • The Swa antigen was excluded from the P1, Dombrock, and Yt blood group systems.
  • The SW locus showed no close linkage to numerous other blood group loci (e.g., ABO, RH, FY).

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  • Exclusion of SW from the p22.1 to p34 segment of chromosome 1 was inferred.

    • Conclusions:

    • The Swa antigen represents a distinct genetic entity, not closely linked to previously identified blood group systems.
    • Further research is needed to fully characterize the SW blood group locus and its chromosomal location.