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Updated: Nov 14, 2025

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor
Published on: September 13, 2018
A novel role of Hippo-Yap/TAZ signaling pathway in lymphatic vascular development
Boksik Cha1, Sungjin Moon2, Wantae Kim3
1Daegu Gyeongbuk Medical Innovation Foundation, Daegu 41061, Korea.
Abstract:
The lymphatic vasculature plays important role in regulating fluid homeostasis, intestinal lipid absorption, and immune surveillance in humans. Malfunction of lymphatic vasculature leads to several human diseases. Understanding the fundamental mechanism in lymphatic vascular development not only expand our knowledge, but also provide a new therapeutic insight. Recently, Hippo-YAP/TAZ signaling pathway, a key mechanism of organ size and tissue homeostasis, has emerged as a critical player that regulate lymphatic specification, sprouting, and maturation. In this review, we discuss the mechanistic regulation and pathophysiological significant of Hippo pathway in lymphatic vascular development. [BMB Reports 2021; 54(6): 285-294].
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