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Gestational age dating using newborn metabolic screening: A validation study in Busia, Uganda

Scott P Oltman1,2, Elizabeth A Jasper3, Richard Kajubi4

  • 1Department of Epidemiology and Biostatistics, University of California San Francisco School of Medicine, San Francisco, California, USA.

Journal of Global Health
|March 11, 2021
PubMed
Summary

No abstract available in PubMed .

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In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
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