Related Experiment Video

Updated: Nov 14, 2025

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

10.7K

Electrocardiographic Left Ventricular Hypertrophy Is Independently Associated With Better Long-Term Outcomes in

Shouji Matsushima1, Hidetaka Kaku2, Nobuyuki Enzan2

  • 1Department of Cardiovascular Medicine, Kyushu University Hospital Fukuoka Japan.

Circulation Reports
|March 11, 2021
PubMed

Insights

Electrocardiogram findings of left ventricular hypertrophy (ECG-LVH) in dilated cardiomyopathy (DCM) patients predict better long-term outcomes. Patients with ECG-LVH showed lower mortality and rehospitalization rates, indicating a positive prognostic role.

Area of Science:

  • Cardiology
  • Heart Failure Research
  • Diagnostic Electrocardiography

Background:

  • Left ventricular hypertrophy (LVH) on ECG (ECG-LVH) is seen in dilated cardiomyopathy (DCM).
  • The prognostic significance of ECG-LVH in DCM patients remains unclear.
  • Assessing ECG-LVH's impact on mortality and rehospitalization in DCM is crucial.

Purpose of the Study:

  • To evaluate the prognostic importance of QRS voltage criteria for LVH (ECG-LVH) in patients with DCM.
  • To determine the association between ECG-LVH and long-term outcomes, including all-cause death and heart failure rehospitalization.

Main Methods:

  • Analysis of 261 DCM patients from the JCARE-CARD prospective registry.
  • Diagnosis of ECG-LVH using Sokolow-Lyon voltage criteria.
  • Mean follow-up of 1.8 years to assess mortality and rehospitalization events.

Main Results:

  • 31.0% of DCM patients (81/261) exhibited ECG-LVH.
  • Patients with ECG-LVH had significantly lower rates of all-cause death (9.0% vs. 20.3%) and composite death/rehospitalization (26.9% vs. 45.9%).
  • Multivariable analysis confirmed ECG-LVH as an independent negative predictor for composite outcomes (HR: 0.358, P=0.049).

Conclusions:

  • ECG-LVH is independently associated with a better long-term prognosis in patients with DCM.
  • The presence of ECG-LVH may indicate a subset of DCM patients with a more favorable outcome.
  • Further research may refine risk stratification using ECG-LVH in DCM management.

Keywords:
Dilated cardiomyopathyLeft ventricular hypertrophyOutcomeQRS voltage

More Related Videos

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography06:34

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography

Published on: October 28, 2020

4.3K
Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography07:11

Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography

Published on: October 28, 2020

3.1K

Related Concept Videos

Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
139
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
138
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
115
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
181
Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
169
Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
198