Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cancer02:18

Cancer

51.9K
Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
51.9K
Tumor Progression02:07

Tumor Progression

6.8K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.8K
Abnormal Proliferation02:23

Abnormal Proliferation

4.9K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.9K
Tumor Immunotherapy01:27

Tumor Immunotherapy

842
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
842
The Tumor Microenvironment02:17

The Tumor Microenvironment

7.2K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
7.2K
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

8.6K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
8.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Modification of protein transfer across blood/cerebrospinal fluid barrier in response to altered plasma protein composition during development.

The European journal of neuroscience·2010
Same author

Effect of minocycline on inflammation-induced damage to the blood-brain barrier and white matter during development.

The European journal of neuroscience·2007
Same author

Blood-CSF barrier function in the rat embryo.

The European journal of neuroscience·2006
Same author

Long-term changes in blood-brain barrier permeability and white matter following prolonged systemic inflammation in early development in the rat.

The European journal of neuroscience·2005
Same author

Breakdown of the blood-brain barrier to proteins in white matter of the developing brain following systemic inflammation.

Cell and tissue research·2005
Same author

Fluorescence in situ hybridization analysis of 25 cases of idiopathic myelofibrosis and two cases of secondary myelofibrosis: monoallelic loss of RB1, D13S319 and D13S25 loci associated with cytogenetic deletion and translocation involving 13q14.

British journal of haematology·2001
Same journal

What the American Medical Association Thinks of the Electronic Reactions of Abrams.

The Dental register·2021
Same journal

A Few Remarks on the Role of the American Dentists in Paris during the Great War.

The Dental register·2021
Same journal

Event and Comment.

The Dental register·2021
Same journal

A Message from Thwaites.

The Dental register·2021
Same journal

Cuspid Relationship and Pyorrhea Alveolaris.

The Dental register·2021
Same journal

Defective Teeth and Nutrition.

The Dental register·2021
See all related articles

Related Experiment Video

Updated: Nov 14, 2025

Tumorsphere Derivation and Treatment from Primary Tumor Cells Isolated from Mouse Rhabdomyosarcomas
09:21

Tumorsphere Derivation and Treatment from Primary Tumor Cells Isolated from Mouse Rhabdomyosarcomas

Published on: September 13, 2019

7.4K

Tumors

A M Potter

    The Dental Register
    |March 11, 2021
    PubMed
    Summary

    No abstract available in PubMed .

    More Related Videos

    Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone
    06:53

    Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone

    Published on: September 9, 2020

    3.0K
    Author Spotlight: Creating Human Vascularized Micro-Tumors as Models for Translational Cancer Research
    07:26

    Author Spotlight: Creating Human Vascularized Micro-Tumors as Models for Translational Cancer Research

    Published on: September 15, 2023

    2.1K

    Related Experiment Videos

    Last Updated: Nov 14, 2025

    Tumorsphere Derivation and Treatment from Primary Tumor Cells Isolated from Mouse Rhabdomyosarcomas
    09:21

    Tumorsphere Derivation and Treatment from Primary Tumor Cells Isolated from Mouse Rhabdomyosarcomas

    Published on: September 13, 2019

    7.4K
    Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone
    06:53

    Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone

    Published on: September 9, 2020

    3.0K
    Author Spotlight: Creating Human Vascularized Micro-Tumors as Models for Translational Cancer Research
    07:26

    Author Spotlight: Creating Human Vascularized Micro-Tumors as Models for Translational Cancer Research

    Published on: September 15, 2023

    2.1K