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Cardiopulmonary arrest following intravenous phenytoin loading
1Emergency Medicine Service, Walter Reed Army Medical Center, Washington, DC.
The American Journal of Emergency Medicine
|May 1, 1988
Summary
Two patients experienced severe adverse events, including cardiopulmonary arrest, after receiving intravenous phenytoin for seizures due to subtherapeutic anticonvulsant levels. This highlights risks associated with manual phenytoin infusion, especially in high-risk patients.
Area of Science:
- Neurology
- Clinical Pharmacology
Background:
- Generalized seizures necessitate prompt management to restore therapeutic anticonvulsant serum levels.
- Subtherapeutic levels can precipitate further seizures or complications.
- Patient risk factors influence treatment choices and monitoring intensity.