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Updated: Nov 14, 2025
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Quantification of Orofacial Phenotypes in Xenopus
Published on: November 6, 2014
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Variations in Orofacial Clefts.
Arezoo Jahanbin1, Abdollah Jamalinasab, Ahmad Ehsan Niazi
1Department of Orthodontics, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.
The Journal of Craniofacial Surgery
|March 11, 2021
Summary
Oral clefts are common birth anomalies, with cleft lip and palate most frequent in boys and isolated cleft palate in girls. Parental consanguinity and family history are significant risk factors.
Area of Science:
- Pediatric Medicine
- Genetics
- Public Health
Background:
- Oral clefts represent a significant global health concern, impacting newborns and requiring comprehensive epidemiological data.
- Understanding the prevalence and risk factors of oral clefts is crucial for effective prevention and intervention strategies.
Purpose of the Study:
- To determine the prevalence of various oral cleft anomalies in a cohort of newborn infants.
- To identify demographic and familial risk factors associated with oral clefts.
Main Methods:
- Retrospective analysis of data from 234 infants diagnosed with cleft anomalies between 2004 and 2019.
- Assessment of demographic parameters, including sex distribution and parental consanguinity and family history.
Main Results:
- Cleft lip and palate was the most prevalent anomaly (66.7%), followed by isolated cleft palate (28.2%).
- Oral clefts were more common in males (54.3%) than females (45.7%), with significant sex-based differences observed for specific cleft types.
- Parental consanguinity (56.4%) and a family history of clefts (20%) were identified as notable risk factors.
Conclusions:
- Cleft lip and palate predominantly affects males, while isolated cleft palate is more common in females.
- Parental consanguinity and a positive family history of clefts are significant risk factors.
- Further research into the genetic and environmental factors influencing cleft anomalies is warranted.
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