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Imaging Approaches to Assessments of Toxicological Oxidative Stress Using Genetically-encoded Fluorogenic Sensors
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COVID-19 and Oxidative Stress.

B V Chernyak1, E N Popova1, A S Prikhodko1,2

  • 1Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, 119991, Russia.

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Summary
This summary is machine-generated.

Oxidative stress significantly contributes to the pathogenesis of COVID-19 and other respiratory viral infections. This review examines the role of oxidative stress and vascular endothelium involvement in SARS-CoV-2 infection.

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Area of Science:

  • * Virology and Immunology
  • * Pathophysiology of Infectious Diseases

Background:

  • * COVID-19, caused by SARS-CoV-2, is a complex disease involving intricate interactions between the virus, host immune system, and systemic responses.
  • * Viral infections, including COVID-19, often lead to cell death, immune activation, and inflammatory cytokine release.
  • * These processes are frequently accompanied by oxidative stress, a critical factor in viral pathogenesis.

Purpose of the Study:

  • * To review current research on the role of oxidative stress in SARS-CoV-2 infections.
  • * To analyze the contribution of oxidative stress in the pathogenesis of other respiratory viral infections.
  • * To investigate the involvement of the vascular endothelium in COVID-19 pathogenesis.

Main Methods:

  • * Comprehensive literature review of studies on COVID-19 and respiratory viral infections.
  • * Analysis of research focusing on oxidative stress mechanisms.
  • * Examination of studies investigating vascular endothelium function in SARS-CoV-2.

Main Results:

  • * Oxidative stress is a key component in the pathogenesis of COVID-19 and other respiratory viral infections.
  • * The interaction between SARS-CoV-2 and host cells triggers significant oxidative stress.
  • * The vascular endothelium plays a crucial role in the development of COVID-19.

Conclusions:

  • * Oxidative stress is a critical factor in the pathophysiology of COVID-19.
  • * Targeting oxidative stress pathways may offer therapeutic strategies for COVID-19.
  • * Further research into vascular endothelium involvement is essential for understanding COVID-19 progression.